The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases
The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases
Growth cones navigate by coupling extracellular guidance cues to directed outgrowth of the actin cytoskeleton through cyclical extension of filopodia and lamellipodia, but the biochemical basis of this coupling is at present unknown. Recent studies have shown that members of the Rho family of small GTPases regulate the formation of filopodia, lamellipodia and stress fibres in fibroblasts, and there are striking morphological similarities between spreading fibroblasts and advancing growth cones. This resemblance suggests that the Rho family of proteins could be the link between incoming signals and the regulation of both actin dynamics and cell-substratum adhesion in the neuronal growth cone.
Actins, Animals, Cytoskeleton, GTP Phosphohydrolases, Humans, Neural Pathways, Neurites, Journal Article, Research Support, Non-U.S. Gov't, Review
496-501
Mackay, D J
588a653e-9785-4a00-be71-4e547850ee4a
Nobes, C D
ff3ae2f6-c6e4-4de0-aaed-db624d6486ec
Hall, Alan
a5b27515-b468-4f87-a7bb-db5e7b0dfaa4
November 1995
Mackay, D J
588a653e-9785-4a00-be71-4e547850ee4a
Nobes, C D
ff3ae2f6-c6e4-4de0-aaed-db624d6486ec
Hall, Alan
a5b27515-b468-4f87-a7bb-db5e7b0dfaa4
Mackay, D J, Nobes, C D and Hall, Alan
(1995)
The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases.
Trends in Neurosciences, 18 (11), .
(doi:10.1016/0166-2236(95)92773-J).
Abstract
Growth cones navigate by coupling extracellular guidance cues to directed outgrowth of the actin cytoskeleton through cyclical extension of filopodia and lamellipodia, but the biochemical basis of this coupling is at present unknown. Recent studies have shown that members of the Rho family of small GTPases regulate the formation of filopodia, lamellipodia and stress fibres in fibroblasts, and there are striking morphological similarities between spreading fibroblasts and advancing growth cones. This resemblance suggests that the Rho family of proteins could be the link between incoming signals and the regulation of both actin dynamics and cell-substratum adhesion in the neuronal growth cone.
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Published date: November 1995
Keywords:
Actins, Animals, Cytoskeleton, GTP Phosphohydrolases, Humans, Neural Pathways, Neurites, Journal Article, Research Support, Non-U.S. Gov't, Review
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Local EPrints ID: 418376
URI: http://eprints.soton.ac.uk/id/eprint/418376
ISSN: 0166-2236
PURE UUID: be6e004d-55fb-4adc-98aa-c5e34c9d0faf
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Date deposited: 05 Mar 2018 17:30
Last modified: 16 Mar 2024 03:05
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Author:
C D Nobes
Author:
Alan Hall
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