Current treatment of double hit and double expressor lymphoma
Current treatment of double hit and double expressor lymphoma
A 60-year-old female presented with abdominal pain and distension. Following computed tomography scans of the abdomen and pelvis, she was taken urgently to the operating room, with the belief that she had appendicitis with perforation. At laparotomy, the findings were consistent with an ovarian carcinoma; there was extensive infiltration of the ovary, bowel, and omental deposits. Cytoreductive surgery was performed including total abdominal hysterectomy and bilateral salpingo-oophorectomy. The final pathology, however, revealed infiltration with medium-sized atypical lymphoid cells positive for CD20, CD10, MYC, BLC2, and BCL6 by immunohistochemistry. MYC and BCL2 translocations were identified by fluorescence in situ hybridization consistent with a diagnosis of high-grade B-cell lymphoma with rearrangements of MYC and BCL2 With the current data available, what is the optimal treatment of this patient?
Journal Article, Review
295-297
Reagan, Patrick M.
3b6a84cc-4034-4d6e-970a-dd3fdb421825
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
8 December 2017
Reagan, Patrick M.
3b6a84cc-4034-4d6e-970a-dd3fdb421825
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Reagan, Patrick M. and Davies, Andrew
(2017)
Current treatment of double hit and double expressor lymphoma.
Hematology, ASH Education Program, 2017 (1), .
(doi:10.1182/asheducation-2017.1.295).
Abstract
A 60-year-old female presented with abdominal pain and distension. Following computed tomography scans of the abdomen and pelvis, she was taken urgently to the operating room, with the belief that she had appendicitis with perforation. At laparotomy, the findings were consistent with an ovarian carcinoma; there was extensive infiltration of the ovary, bowel, and omental deposits. Cytoreductive surgery was performed including total abdominal hysterectomy and bilateral salpingo-oophorectomy. The final pathology, however, revealed infiltration with medium-sized atypical lymphoid cells positive for CD20, CD10, MYC, BLC2, and BCL6 by immunohistochemistry. MYC and BCL2 translocations were identified by fluorescence in situ hybridization consistent with a diagnosis of high-grade B-cell lymphoma with rearrangements of MYC and BCL2 With the current data available, what is the optimal treatment of this patient?
This record has no associated files available for download.
More information
Published date: 8 December 2017
Keywords:
Journal Article, Review
Identifiers
Local EPrints ID: 418615
URI: http://eprints.soton.ac.uk/id/eprint/418615
ISSN: 1520-4391
PURE UUID: 5028dfb8-4b66-41f5-bfc8-e7e99bc3f6ed
Catalogue record
Date deposited: 12 Mar 2018 17:31
Last modified: 16 Mar 2024 03:58
Export record
Altmetrics
Contributors
Author:
Patrick M. Reagan
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
