Non-pulmonary immune functions of surfactant proteins A and D
Non-pulmonary immune functions of surfactant proteins A and D
Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, the eye, ear, nasal compartment, central nervous system, the coronary artery and the skin. The functions of SP-A and SP-D at these sites are a relatively underinvestigated area, but it is emerging that both SP-A and SP-D contribute significantly to the regulation of inflammation and protection from infection at these sites. This review presents our current understanding of the roles of SP-A and SP-D in non-pulmonary sites.
Female reproductive tract, Gastrointestinal tract, Surfactant protein A, Surfactant protein D, Urinary tract
3-11
Ujma, Sylvia
9bedec86-f62a-4a50-905d-48f47fd2e78c
Horsnell, William G.C.
b490aa17-3f96-49d3-8b02-821bf14e2537
Katz, Arieh A.
936bf457-8b2e-4c8d-a8ef-5f639f37e2da
Clark, Howard W.
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Schäfer, Georgia
ce1d65c9-75e2-4b4d-83be-5baa0d9a5928
1 January 2017
Ujma, Sylvia
9bedec86-f62a-4a50-905d-48f47fd2e78c
Horsnell, William G.C.
b490aa17-3f96-49d3-8b02-821bf14e2537
Katz, Arieh A.
936bf457-8b2e-4c8d-a8ef-5f639f37e2da
Clark, Howard W.
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Schäfer, Georgia
ce1d65c9-75e2-4b4d-83be-5baa0d9a5928
Ujma, Sylvia, Horsnell, William G.C., Katz, Arieh A., Clark, Howard W. and Schäfer, Georgia
(2017)
Non-pulmonary immune functions of surfactant proteins A and D.
Journal of Innate Immunity, 9 (1), .
(doi:10.1159/000451026).
Abstract
Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, the eye, ear, nasal compartment, central nervous system, the coronary artery and the skin. The functions of SP-A and SP-D at these sites are a relatively underinvestigated area, but it is emerging that both SP-A and SP-D contribute significantly to the regulation of inflammation and protection from infection at these sites. This review presents our current understanding of the roles of SP-A and SP-D in non-pulmonary sites.
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Accepted/In Press date: 26 September 2016
e-pub ahead of print date: 29 October 2016
Published date: 1 January 2017
Keywords:
Female reproductive tract, Gastrointestinal tract, Surfactant protein A, Surfactant protein D, Urinary tract
Identifiers
Local EPrints ID: 418629
URI: http://eprints.soton.ac.uk/id/eprint/418629
ISSN: 1662-811X
PURE UUID: ff311f88-6e56-4e71-870b-a821b8f31c5d
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Date deposited: 13 Mar 2018 17:30
Last modified: 17 Mar 2024 11:59
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Contributors
Author:
Sylvia Ujma
Author:
William G.C. Horsnell
Author:
Arieh A. Katz
Author:
Howard W. Clark
Author:
Georgia Schäfer
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