The University of Southampton
×
Filter your search:
University of Southampton Institutional Repository

Trial forge guidance 1: What is a Study Within A Trial (SWAT)?

Trial forge guidance 1: What is a Study Within A Trial (SWAT)?
Trial forge guidance 1: What is a Study Within A Trial (SWAT)?

Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency. One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

1745-6215
Treweek, Shaun
2e309a54-c618-4a59-b0fd-2b878034cb98
Bevan, Simon
87cb0f43-3e56-4b29-ae02-94ff929980c6
Bower, Peter
ec553157-a170-4219-8b55-2df813846e44
Campbell, Marion
9e543066-f54d-4a5f-96d0-d40c2e35e27a
Christie, Jacquie
2fb061d1-b689-4aa1-a970-b5869bfa5a0e
Clarke, Mike
1baad8d3-fb35-4f7f-a9cf-1ff7161c1d0a
Collett, Clive
16387da4-ae96-4cee-9e30-0cb94ad21f50
Cotton, Seonaidh
294f5ff5-98fc-4330-ab75-2d42f323e3f6
Devane, Declan
ac8af4dc-f7e3-40c3-9bfb-a269f6432109
El Feky, Adel
a8dbf6e5-c3c3-45ba-b01f-59a01cb22b16
Flemyng, Ella
a2d050f9-0856-4797-b80f-b6471fcb4b00
Galvin, Sandra
12bab9ac-3893-40e0-87e3-7b736cc00987
Gardner, Heidi
d71463e5-7a95-42ac-a9f3-38fc5c0b6f8f
Gillies, Katie
04e9bf92-6bb0-4e0c-9176-56a40d34183e
Jansen, Jan
f75dbf51-69d8-4eec-b196-89f06e81e379
Littleford, Roberta
30f1bad3-9431-45d3-9880-bc97a93aba3b
Parker, Adwoa
37113a4f-9686-4a61-b272-72e10240fd6a
Ramsay, Craig
2f8071ed-9d54-4d8a-9473-d8fa15d5e6d5
Restrup, Lynne
7c70d6da-23a0-4564-a321-d8fa4d0e70b1
Sullivan, Frank
54fec8ce-02e9-4aab-b2e6-c32e668458cd
Torgerson, David
2b48b54a-4cc1-4833-864f-5b3d1b9fbc66
Tremain, Liz
a8b2917b-73d8-4fb8-bc05-413f2a6265f3
Westmore, Matthew
e31f9482-d7b0-47ae-bc7c-b47050282916
Williamson, Paula R.
1027450c-aa72-4e64-b516-668435bc4cb5
Treweek, Shaun
2e309a54-c618-4a59-b0fd-2b878034cb98
Bevan, Simon
87cb0f43-3e56-4b29-ae02-94ff929980c6
Bower, Peter
ec553157-a170-4219-8b55-2df813846e44
Campbell, Marion
9e543066-f54d-4a5f-96d0-d40c2e35e27a
Christie, Jacquie
2fb061d1-b689-4aa1-a970-b5869bfa5a0e
Clarke, Mike
1baad8d3-fb35-4f7f-a9cf-1ff7161c1d0a
Collett, Clive
16387da4-ae96-4cee-9e30-0cb94ad21f50
Cotton, Seonaidh
294f5ff5-98fc-4330-ab75-2d42f323e3f6
Devane, Declan
ac8af4dc-f7e3-40c3-9bfb-a269f6432109
El Feky, Adel
a8dbf6e5-c3c3-45ba-b01f-59a01cb22b16
Flemyng, Ella
a2d050f9-0856-4797-b80f-b6471fcb4b00
Galvin, Sandra
12bab9ac-3893-40e0-87e3-7b736cc00987
Gardner, Heidi
d71463e5-7a95-42ac-a9f3-38fc5c0b6f8f
Gillies, Katie
04e9bf92-6bb0-4e0c-9176-56a40d34183e
Jansen, Jan
f75dbf51-69d8-4eec-b196-89f06e81e379
Littleford, Roberta
30f1bad3-9431-45d3-9880-bc97a93aba3b
Parker, Adwoa
37113a4f-9686-4a61-b272-72e10240fd6a
Ramsay, Craig
2f8071ed-9d54-4d8a-9473-d8fa15d5e6d5
Restrup, Lynne
7c70d6da-23a0-4564-a321-d8fa4d0e70b1
Sullivan, Frank
54fec8ce-02e9-4aab-b2e6-c32e668458cd
Torgerson, David
2b48b54a-4cc1-4833-864f-5b3d1b9fbc66
Tremain, Liz
a8b2917b-73d8-4fb8-bc05-413f2a6265f3
Westmore, Matthew
e31f9482-d7b0-47ae-bc7c-b47050282916
Williamson, Paula R.
1027450c-aa72-4e64-b516-668435bc4cb5

Treweek, Shaun, Bevan, Simon, Bower, Peter, Campbell, Marion, Christie, Jacquie, Clarke, Mike, Collett, Clive, Cotton, Seonaidh, Devane, Declan, El Feky, Adel, Flemyng, Ella, Galvin, Sandra, Gardner, Heidi, Gillies, Katie, Jansen, Jan, Littleford, Roberta, Parker, Adwoa, Ramsay, Craig, Restrup, Lynne, Sullivan, Frank, Torgerson, David, Tremain, Liz, Westmore, Matthew and Williamson, Paula R. (2018) Trial forge guidance 1: What is a Study Within A Trial (SWAT)? Trials, 19 (1), [139]. (doi:10.1186/s13063-018-2535-5).

Record type: Letter

Abstract

Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency. One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

Text
document-ST - Version of Record
Available under License Creative Commons Attribution.
Download (470kB)

More information

Accepted/In Press date: 7 February 2018
e-pub ahead of print date: 23 February 2018

Identifiers

Local EPrints ID: 418740
URI: http://eprints.soton.ac.uk/id/eprint/418740
DOI: doi:10.1186/s13063-018-2535-5
ISSN: 1745-6215
PURE UUID: 4e219b9f-a329-4920-96de-bce4969b2fce

Catalogue record

Date deposited: 21 Mar 2018 17:30
Last modified: 15 Mar 2024 19:00

Export record

Altmetrics

Contributors

Author: Shaun Treweek
Author: Simon Bevan
Author: Peter Bower
Author: Marion Campbell
Author: Jacquie Christie
Author: Mike Clarke
Author: Clive Collett
Author: Seonaidh Cotton
Author: Declan Devane
Author: Adel El Feky
Author: Ella Flemyng
Author: Sandra Galvin
Author: Heidi Gardner
Author: Katie Gillies
Author: Jan Jansen
Author: Roberta Littleford
Author: Adwoa Parker
Author: Craig Ramsay
Author: Lynne Restrup
Author: Frank Sullivan
Author: David Torgerson
Author: Liz Tremain
Author: Matthew Westmore
Author: Paula R. Williamson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff additional information
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×