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Trial forge guidance 1: What is a Study Within A Trial (SWAT)?

Trial forge guidance 1: What is a Study Within A Trial (SWAT)?
Trial forge guidance 1: What is a Study Within A Trial (SWAT)?

Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency. One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

1745-6215
Treweek, Shaun
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Bevan, Simon
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Bower, Peter
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Campbell, Marion
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Christie, Jacquie
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Clarke, Mike
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Collett, Clive
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Cotton, Seonaidh
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Devane, Declan
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El Feky, Adel
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Flemyng, Ella
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Galvin, Sandra
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Jansen, Jan
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Littleford, Roberta
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Parker, Adwoa
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Ramsay, Craig
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Restrup, Lynne
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Sullivan, Frank
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Torgerson, David
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Tremain, Liz
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Westmore, Matthew
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Williamson, Paula R.
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Treweek, Shaun
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Bevan, Simon
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Bower, Peter
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Campbell, Marion
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Christie, Jacquie
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Clarke, Mike
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Collett, Clive
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Cotton, Seonaidh
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Devane, Declan
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El Feky, Adel
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Flemyng, Ella
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Galvin, Sandra
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Gardner, Heidi
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Gillies, Katie
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Jansen, Jan
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Littleford, Roberta
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Parker, Adwoa
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Ramsay, Craig
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Restrup, Lynne
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Sullivan, Frank
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Torgerson, David
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Tremain, Liz
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Westmore, Matthew
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Williamson, Paula R.
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Treweek, Shaun, Bevan, Simon, Bower, Peter, Campbell, Marion, Christie, Jacquie, Clarke, Mike, Collett, Clive, Cotton, Seonaidh, Devane, Declan, El Feky, Adel, Flemyng, Ella, Galvin, Sandra, Gardner, Heidi, Gillies, Katie, Jansen, Jan, Littleford, Roberta, Parker, Adwoa, Ramsay, Craig, Restrup, Lynne, Sullivan, Frank, Torgerson, David, Tremain, Liz, Westmore, Matthew and Williamson, Paula R. (2018) Trial forge guidance 1: What is a Study Within A Trial (SWAT)? Trials, 19 (1). (doi:10.1186/s13063-018-2535-5).

Record type: Letter

Abstract

Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency. One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

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Accepted/In Press date: 7 February 2018
e-pub ahead of print date: 23 February 2018

Identifiers

Local EPrints ID: 418740
URI: https://eprints.soton.ac.uk/id/eprint/418740
ISSN: 1745-6215
PURE UUID: 4e219b9f-a329-4920-96de-bce4969b2fce

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Date deposited: 21 Mar 2018 17:30
Last modified: 19 Jul 2019 17:24

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Contributors

Author: Shaun Treweek
Author: Simon Bevan
Author: Peter Bower
Author: Marion Campbell
Author: Jacquie Christie
Author: Mike Clarke
Author: Clive Collett
Author: Seonaidh Cotton
Author: Declan Devane
Author: Adel El Feky
Author: Ella Flemyng
Author: Sandra Galvin
Author: Heidi Gardner
Author: Katie Gillies
Author: Jan Jansen
Author: Roberta Littleford
Author: Adwoa Parker
Author: Craig Ramsay
Author: Lynne Restrup
Author: Frank Sullivan
Author: David Torgerson
Author: Liz Tremain
Author: Paula R. Williamson

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