Integrins promote axonal regeneration after injury of the nervous system
Integrins promote axonal regeneration after injury of the nervous system
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
1339-1362
Nieuwenhuis, Bart
1d757056-2c95-454f-bdbb-697d6352370f
Haenzi, Barbara
7188c310-17e7-4777-8bf9-04a8f99e3c94
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Verhaagen, Joost
1031fc26-2fd9-4df1-a06a-0922bbd48d83
Fawcett, James
e6e19417-eb0e-483f-9fcb-783e3d835a07
August 2018
Nieuwenhuis, Bart
1d757056-2c95-454f-bdbb-697d6352370f
Haenzi, Barbara
7188c310-17e7-4777-8bf9-04a8f99e3c94
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Verhaagen, Joost
1031fc26-2fd9-4df1-a06a-0922bbd48d83
Fawcett, James
e6e19417-eb0e-483f-9fcb-783e3d835a07
Nieuwenhuis, Bart, Haenzi, Barbara, Andrews, Melissa, Verhaagen, Joost and Fawcett, James
(2018)
Integrins promote axonal regeneration after injury of the nervous system.
Biological Reviews, 93 (3), .
(doi:10.1111/brv.12398).
Abstract
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
Text
biological reviews - Integrins promote axonal regeneration after injury of the nervous system
- Accepted Manuscript
Text
Nieuwenhuis_et_al-2018-Biological_Reviews
- Version of Record
More information
Accepted/In Press date: 11 January 2018
e-pub ahead of print date: 15 February 2018
Published date: August 2018
Identifiers
Local EPrints ID: 418870
URI: http://eprints.soton.ac.uk/id/eprint/418870
ISSN: 1464-7931
PURE UUID: fe434bdf-4404-4faf-a904-8676aec34e55
Catalogue record
Date deposited: 23 Mar 2018 17:30
Last modified: 16 Mar 2024 06:22
Export record
Altmetrics
Contributors
Author:
Bart Nieuwenhuis
Author:
Barbara Haenzi
Author:
Joost Verhaagen
Author:
James Fawcett
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
