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Integrins promote axonal regeneration after injury of the nervous system

Integrins promote axonal regeneration after injury of the nervous system
Integrins promote axonal regeneration after injury of the nervous system
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
1464-7931
1339-1362
Nieuwenhuis, Bart
1d757056-2c95-454f-bdbb-697d6352370f
Haenzi, Barbara
7188c310-17e7-4777-8bf9-04a8f99e3c94
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Verhaagen, Joost
1031fc26-2fd9-4df1-a06a-0922bbd48d83
Fawcett, James
e6e19417-eb0e-483f-9fcb-783e3d835a07
Nieuwenhuis, Bart
1d757056-2c95-454f-bdbb-697d6352370f
Haenzi, Barbara
7188c310-17e7-4777-8bf9-04a8f99e3c94
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Verhaagen, Joost
1031fc26-2fd9-4df1-a06a-0922bbd48d83
Fawcett, James
e6e19417-eb0e-483f-9fcb-783e3d835a07

Nieuwenhuis, Bart, Haenzi, Barbara, Andrews, Melissa, Verhaagen, Joost and Fawcett, James (2018) Integrins promote axonal regeneration after injury of the nervous system. Biological Reviews, 93 (3), 1339-1362. (doi:10.1111/brv.12398).

Record type: Review

Abstract

Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.

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biological reviews - Integrins promote axonal regeneration after injury of the nervous system - Accepted Manuscript
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Nieuwenhuis_et_al-2018-Biological_Reviews - Version of Record
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More information

Accepted/In Press date: 11 January 2018
e-pub ahead of print date: 15 February 2018
Published date: August 2018

Identifiers

Local EPrints ID: 418870
URI: http://eprints.soton.ac.uk/id/eprint/418870
ISSN: 1464-7931
PURE UUID: fe434bdf-4404-4faf-a904-8676aec34e55
ORCID for Melissa Andrews: ORCID iD orcid.org/0000-0001-5960-5619

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Date deposited: 23 Mar 2018 17:30
Last modified: 26 Nov 2021 06:06

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Contributors

Author: Bart Nieuwenhuis
Author: Barbara Haenzi
Author: Melissa Andrews ORCID iD
Author: Joost Verhaagen
Author: James Fawcett

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