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Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: a retrospective cohort study in a single institution

Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: a retrospective cohort study in a single institution
Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: a retrospective cohort study in a single institution

Background: Alpha-gal syndrome is a hypersensitivity reaction to red meat mediated by IgE antibody specific to galactose-α-1,3-galactose carbohydrate (alpha-gal). Amblyomma tick bites are associated with this condition, but the pathophysiology is not understood. Objective: To clarify the mechanism of development of alpha-gal syndrome after tick bites. Methods: We compared alpha-gal antibody levels between patients with and without a history of tick bites and examined histologic stainings of tick bite lesions between patients with and without detectable alpha-gal IgE antibody. Results: Patients who had ≥2 tick bites had higher levels of alpha-gal IgE antibody compared with those with only 1 tick bite or healthy individuals. On histologic investigation, greater numbers of basophils and eosinophils, but not mast cells, were observed infiltrating lesions of patients with ≥2 tick bites compared with those with 1 tick bite. Type 2 cytokine-producing T-cell infiltration was predominantly observed in such patients. Limitations: The study was conducted at a single institution in Japan. Conclusion: In Amblyomma tick bite lesions, basophils; eosinophils; and type 2, cytokine-producing T cells infiltrate the skin and alpha-gal IgE antibodies are produced. These findings provide a potential mechanistic connection between Amblyomma bites and red meat hypersensitivity.

alpha-gal syndrome, basophil, eosinophil, interferon γ, interleukin 4, tick bite, type 2 T cell
0190-9622
Hashizume, Hideo
77e449ba-af57-4981-ab49-4f66025dbefe
Fujiyama, Toshiharu
e93f0b23-64db-4162-ae29-2ba66395389c
Umayahara, Takatsune
af380495-2cac-4e8b-b868-52323ea7f666
Kageyama, Reiko
cb4ca9d3-654f-481a-bcc6-efdc30145016
Walls, Andrew F.
aaa7e455-0562-4b4c-94f5-ec29c74b1bfe
Satoh, Takahiro
5a81aa0a-0463-4acd-9377-5e4443e54d96
Hashizume, Hideo
77e449ba-af57-4981-ab49-4f66025dbefe
Fujiyama, Toshiharu
e93f0b23-64db-4162-ae29-2ba66395389c
Umayahara, Takatsune
af380495-2cac-4e8b-b868-52323ea7f666
Kageyama, Reiko
cb4ca9d3-654f-481a-bcc6-efdc30145016
Walls, Andrew F.
aaa7e455-0562-4b4c-94f5-ec29c74b1bfe
Satoh, Takahiro
5a81aa0a-0463-4acd-9377-5e4443e54d96

Hashizume, Hideo, Fujiyama, Toshiharu, Umayahara, Takatsune, Kageyama, Reiko, Walls, Andrew F. and Satoh, Takahiro (2017) Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: a retrospective cohort study in a single institution. Journal of the American Academy of Dermatology. (doi:10.1016/j.jaad.2017.12.028).

Record type: Article

Abstract

Background: Alpha-gal syndrome is a hypersensitivity reaction to red meat mediated by IgE antibody specific to galactose-α-1,3-galactose carbohydrate (alpha-gal). Amblyomma tick bites are associated with this condition, but the pathophysiology is not understood. Objective: To clarify the mechanism of development of alpha-gal syndrome after tick bites. Methods: We compared alpha-gal antibody levels between patients with and without a history of tick bites and examined histologic stainings of tick bite lesions between patients with and without detectable alpha-gal IgE antibody. Results: Patients who had ≥2 tick bites had higher levels of alpha-gal IgE antibody compared with those with only 1 tick bite or healthy individuals. On histologic investigation, greater numbers of basophils and eosinophils, but not mast cells, were observed infiltrating lesions of patients with ≥2 tick bites compared with those with 1 tick bite. Type 2 cytokine-producing T-cell infiltration was predominantly observed in such patients. Limitations: The study was conducted at a single institution in Japan. Conclusion: In Amblyomma tick bite lesions, basophils; eosinophils; and type 2, cytokine-producing T cells infiltrate the skin and alpha-gal IgE antibodies are produced. These findings provide a potential mechanistic connection between Amblyomma bites and red meat hypersensitivity.

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Accepted/In Press date: 5 December 2017
e-pub ahead of print date: 19 December 2017
Keywords: alpha-gal syndrome, basophil, eosinophil, interferon γ, interleukin 4, tick bite, type 2 T cell

Identifiers

Local EPrints ID: 418877
URI: https://eprints.soton.ac.uk/id/eprint/418877
ISSN: 0190-9622
PURE UUID: aaeca59b-0db0-44fa-8748-6e4ddf8505d4

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Date deposited: 23 Mar 2018 17:30
Last modified: 13 Mar 2019 18:46

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Contributors

Author: Hideo Hashizume
Author: Toshiharu Fujiyama
Author: Takatsune Umayahara
Author: Reiko Kageyama
Author: Andrew F. Walls
Author: Takahiro Satoh

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