The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Objective measures for detecting the auditory brainstem response: comparisons of specificity, sensitivity and detection time

Objective measures for detecting the auditory brainstem response: comparisons of specificity, sensitivity and detection time
Objective measures for detecting the auditory brainstem response: comparisons of specificity, sensitivity and detection time
Objective: to evaluate and compare the specificity, sensitivity and detection time of various time-domain and multi-band frequency domainmethods when detecting the auditory brainstem response (ABR).

Design: simulations and subject recorded data were used to assess and compare the performance of the Hotelling’s T2 test (applied in either time or frequency domain), two versions of the modified q-sample uniform scores test and both the Fsp and Fmp, which were evaluated using both conventional F-distributions with assumed degrees of freedom and a bootstrap approach.

Study sample: data consisted of click-evoked ABRs and recordings of EEG background activity from 12 to 17 normal hearing adults, respectively.

Results: an overall advantage in sensitivity and detection time was demonstrated for the Hotelling’s T2 test. The false-positive rates (FPRs) of the Fsp and Fmp were also closer to the nominal alpha-level when evaluating statistical significance using the bootstrap approach, as opposed to using conventional F-distributions. The FPRs of the remaining methods were slightly higher than expected.

Conclusions: in this work, Hotelling’s T2 outperformed the alternative methods for automatically detecting ABRs. Its promise as a sensitive and efficient detection method should now be tested in a larger clinical study.
Auditory brainstem response detection, Hotelling’s T2, Fsp, Fmp, bootstrapping, modified fourier series
468-478
Chesnaye, Michael
5f337509-3255-4322-b1bf-d4d3836b36ec
Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a
Harte, J.M.
20107083-3305-4997-8426-0372ff0b9954
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a
Chesnaye, Michael
5f337509-3255-4322-b1bf-d4d3836b36ec
Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a
Harte, J.M.
20107083-3305-4997-8426-0372ff0b9954
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a

Chesnaye, Michael, Bell, Steven, Harte, J.M. and Simpson, David (2018) Objective measures for detecting the auditory brainstem response: comparisons of specificity, sensitivity and detection time. International Journal of Audiology, 57 (6), 468-478. (doi:10.1080/14992027.2018.1447697).

Record type: Article

Abstract

Objective: to evaluate and compare the specificity, sensitivity and detection time of various time-domain and multi-band frequency domainmethods when detecting the auditory brainstem response (ABR).

Design: simulations and subject recorded data were used to assess and compare the performance of the Hotelling’s T2 test (applied in either time or frequency domain), two versions of the modified q-sample uniform scores test and both the Fsp and Fmp, which were evaluated using both conventional F-distributions with assumed degrees of freedom and a bootstrap approach.

Study sample: data consisted of click-evoked ABRs and recordings of EEG background activity from 12 to 17 normal hearing adults, respectively.

Results: an overall advantage in sensitivity and detection time was demonstrated for the Hotelling’s T2 test. The false-positive rates (FPRs) of the Fsp and Fmp were also closer to the nominal alpha-level when evaluating statistical significance using the bootstrap approach, as opposed to using conventional F-distributions. The FPRs of the remaining methods were slightly higher than expected.

Conclusions: in this work, Hotelling’s T2 outperformed the alternative methods for automatically detecting ABRs. Its promise as a sensitive and efficient detection method should now be tested in a larger clinical study.

Text
M Chesnaye IJA Manuscript Main Document Final Version - Accepted Manuscript
Download (4MB)
Text
Objective measures for detecting the auditory brainstem response comparisons of specificity sensitivity and detection time - Version of Record
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 18 February 2018
e-pub ahead of print date: 14 March 2018
Published date: 3 June 2018
Keywords: Auditory brainstem response detection, Hotelling’s T2, Fsp, Fmp, bootstrapping, modified fourier series

Identifiers

Local EPrints ID: 418878
URI: http://eprints.soton.ac.uk/id/eprint/418878
PURE UUID: a104901e-67ac-41d8-9823-52ca16c691a9

Catalogue record

Date deposited: 23 Mar 2018 17:30
Last modified: 25 Nov 2021 17:23

Export record

Altmetrics

Contributors

Author: Michael Chesnaye
Author: Steven Bell
Author: J.M. Harte
Author: David Simpson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×