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A three-generation study on the association of tobacco smoking with asthma

A three-generation study on the association of tobacco smoking with asthma
A three-generation study on the association of tobacco smoking with asthma
Background:
Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.
Methods:
Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.
Results:
Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55).
Conclusions:
Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
Funding:
European Union (Horizon 2020, GA-633212).
0300-5771
1106-1107
Accordini, Simone
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Calciano, Lucia
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Johannessen, Ane
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Portas, Laura
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Benediktsdóttir, Bryndis
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Bertelsen, Randi Jacobsen
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Bråbäck, Lennart
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Carsin, Anne-elie
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Dharmage, Shyamali C
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Dratva, Julia
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Forsberg, Bertil
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Gomez Real, Francisco
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Heinrich, Joachim
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Holloway, John
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Holm, Mathias
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Janson, Christer
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Jögi, Rain
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Leynaert, Bénédicte
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Malinovschi, Andrei
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Marcon, Alessandro
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Martínez-moratalla Rovira, Jesús
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Raherison, Chantal
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Sánchez-ramos, José Luis
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Schlünssen, Vivi
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Bono, Roberto
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Corsico, Angelo G.
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Demoly, Pascal
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Dorado Arenas, Sandra
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Nowak, Dennis
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Pin, Isabelle
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Weyler, Joost
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Jarvis, Deborah
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Svanes, Cecilie
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Accordini, Simone
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Calciano, Lucia
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Johannessen, Ane
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Portas, Laura
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Bertelsen, Randi Jacobsen
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Carsin, Anne-elie
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Dharmage, Shyamali C
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Dratva, Julia
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Forsberg, Bertil
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Holm, Mathias
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Janson, Christer
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Jögi, Rain
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Leynaert, Bénédicte
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Malinovschi, Andrei
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Raherison, Chantal
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Sánchez-ramos, José Luis
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Schlünssen, Vivi
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Bono, Roberto
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Corsico, Angelo G.
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Demoly, Pascal
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Dorado Arenas, Sandra
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Nowak, Dennis
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Pin, Isabelle
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Weyler, Joost
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Jarvis, Deborah
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Svanes, Cecilie
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Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Portas, Laura, Benediktsdóttir, Bryndis, Bertelsen, Randi Jacobsen, Bråbäck, Lennart, Carsin, Anne-elie, Dharmage, Shyamali C, Dratva, Julia, Forsberg, Bertil, Gomez Real, Francisco, Heinrich, Joachim, Holloway, John, Holm, Mathias, Janson, Christer, Jögi, Rain, Leynaert, Bénédicte, Malinovschi, Andrei, Marcon, Alessandro, Martínez-moratalla Rovira, Jesús, Raherison, Chantal, Sánchez-ramos, José Luis, Schlünssen, Vivi, Bono, Roberto, Corsico, Angelo G., Demoly, Pascal, Dorado Arenas, Sandra, Nowak, Dennis, Pin, Isabelle, Weyler, Joost, Jarvis, Deborah and Svanes, Cecilie (2018) A three-generation study on the association of tobacco smoking with asthma. International journal of epidemiology, 47 (4), 1106-1107. (doi:10.1093/ije/dyy031).

Record type: Article

Abstract

Background:
Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.
Methods:
Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.
Results:
Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55).
Conclusions:
Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
Funding:
European Union (Horizon 2020, GA-633212).

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Accepted/In Press date: 20 February 2018
e-pub ahead of print date: 9 March 2018
Published date: 1 August 2018

Identifiers

Local EPrints ID: 418884
URI: https://eprints.soton.ac.uk/id/eprint/418884
ISSN: 0300-5771
PURE UUID: 855a703e-78b8-40fa-b17e-11ce7ff764cc
ORCID for John Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 23 Mar 2018 17:30
Last modified: 14 Mar 2019 01:50

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Contributors

Author: Simone Accordini
Author: Lucia Calciano
Author: Ane Johannessen
Author: Laura Portas
Author: Bryndis Benediktsdóttir
Author: Randi Jacobsen Bertelsen
Author: Lennart Bråbäck
Author: Anne-elie Carsin
Author: Shyamali C Dharmage
Author: Julia Dratva
Author: Bertil Forsberg
Author: Francisco Gomez Real
Author: Joachim Heinrich
Author: John Holloway ORCID iD
Author: Mathias Holm
Author: Christer Janson
Author: Rain Jögi
Author: Bénédicte Leynaert
Author: Andrei Malinovschi
Author: Alessandro Marcon
Author: Jesús Martínez-moratalla Rovira
Author: Chantal Raherison
Author: José Luis Sánchez-ramos
Author: Vivi Schlünssen
Author: Roberto Bono
Author: Angelo G. Corsico
Author: Pascal Demoly
Author: Sandra Dorado Arenas
Author: Dennis Nowak
Author: Isabelle Pin
Author: Joost Weyler
Author: Deborah Jarvis
Author: Cecilie Svanes

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