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Sex-specific expression of apolipoprotein levels following replenishment of vitamin D

Sex-specific expression of apolipoprotein levels following replenishment of vitamin D
Sex-specific expression of apolipoprotein levels following replenishment of vitamin D
Numerous studies have been done to establish the relationship between vitamin D and lipids, yet a definitive causal link is not found. This interventional study aims to evaluate and compare levels of apolipoproteins among vitamin D deficient subjects at baseline and after they achieved full vitamin D status correction.120 Saudi adults with vitamin D deficiency [25(OH)D < 50nmol/l] were recruited and given 50,000IU cholecalciferol weekly for first 2 months, then twice a month for next 2 months, followed by daily 1000IU until month 6. Blood samples were taken at baseline and after 6 months. Serum 25(OH)D, lipid profile and apolipoproteins (A1, A2, B, C1, C2, C3, E and H) were analyzed using commercially available kits. Overall, serum 25(OH)D increased significantly (63.3 ± 16.5nmol/l at end of study vs. 32.5 ± 10.8 at baseline; p < 0.0001). In parallel, a significant increase in apolipoproteins C1, C2, C3 and E (all p-values < 0.01) and a significant decrease in apolipoprotein B (p=0.02) was observed. Following, stratification according to sex, apolipoproteins C2 and C3 significantly increased only in males (p-values < 0.01) while apolipoprotein C1 significantly increased only in females (p < 0.01). In addition, apolipoprotein B significantly decreased only in females (p=0.002). These results suggests role of vitamin D in modulation of circulating levels of lipoproteins. The sexual dimorphism observed in circulating levels of measured apolipoproteins following vitamin D correction may explain, in part, known sexual disparity in the events of cardiometabolic health.
0960-0760
Al-Daghri, Nasser M.
a8c55fec-b69e-47eb-9d48-5a259eaac01c
Wani, Kaiser
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Sabico, Shaun
dd062ab8-a57c-4b27-a35c-b2d0d6b6b0f8
Garbis, Spiros
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Chrousos, George P.
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Amer, Osama E.
b6a4a7e5-03e2-48d3-b683-eaa39ae8a9c0
Ansari, Mohammed Ghouse Ahmed
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Al-Saleh, Yousef
b6a30c8e-441b-418f-9c77-cf61799fd2b1
Aljohani, Naji J.
a5870d56-7d6f-46ae-8e7a-f63f0c810c13
Al-Attas, Omar S.
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Alokail, Majed S.
9adf2d61-d9f7-4095-bc36-701f0680646a
Al-Daghri, Nasser M.
a8c55fec-b69e-47eb-9d48-5a259eaac01c
Wani, Kaiser
44ab416a-4405-4b5d-8061-5defb73af5df
Sabico, Shaun
dd062ab8-a57c-4b27-a35c-b2d0d6b6b0f8
Garbis, Spiros
7067fd19-50c9-4d42-9611-f370289470bd
Chrousos, George P.
28beffd9-c486-4cf4-a012-06745681d811
Amer, Osama E.
b6a4a7e5-03e2-48d3-b683-eaa39ae8a9c0
Ansari, Mohammed Ghouse Ahmed
6f203ab7-91ef-4802-a837-4c3e06a80111
Al-Saleh, Yousef
b6a30c8e-441b-418f-9c77-cf61799fd2b1
Aljohani, Naji J.
a5870d56-7d6f-46ae-8e7a-f63f0c810c13
Al-Attas, Omar S.
ae24b43e-3979-4d3f-ae7b-a9a77a113294
Alokail, Majed S.
9adf2d61-d9f7-4095-bc36-701f0680646a

Al-Daghri, Nasser M., Wani, Kaiser, Sabico, Shaun, Garbis, Spiros, Chrousos, George P., Amer, Osama E., Ansari, Mohammed Ghouse Ahmed, Al-Saleh, Yousef, Aljohani, Naji J., Al-Attas, Omar S. and Alokail, Majed S. (2017) Sex-specific expression of apolipoprotein levels following replenishment of vitamin D. The Journal of Steroid Biochemistry and Molecular Biology. (doi:10.1016/j.jsbmb.2017.12.005).

Record type: Review

Abstract

Numerous studies have been done to establish the relationship between vitamin D and lipids, yet a definitive causal link is not found. This interventional study aims to evaluate and compare levels of apolipoproteins among vitamin D deficient subjects at baseline and after they achieved full vitamin D status correction.120 Saudi adults with vitamin D deficiency [25(OH)D < 50nmol/l] were recruited and given 50,000IU cholecalciferol weekly for first 2 months, then twice a month for next 2 months, followed by daily 1000IU until month 6. Blood samples were taken at baseline and after 6 months. Serum 25(OH)D, lipid profile and apolipoproteins (A1, A2, B, C1, C2, C3, E and H) were analyzed using commercially available kits. Overall, serum 25(OH)D increased significantly (63.3 ± 16.5nmol/l at end of study vs. 32.5 ± 10.8 at baseline; p < 0.0001). In parallel, a significant increase in apolipoproteins C1, C2, C3 and E (all p-values < 0.01) and a significant decrease in apolipoprotein B (p=0.02) was observed. Following, stratification according to sex, apolipoproteins C2 and C3 significantly increased only in males (p-values < 0.01) while apolipoprotein C1 significantly increased only in females (p < 0.01). In addition, apolipoprotein B significantly decreased only in females (p=0.002). These results suggests role of vitamin D in modulation of circulating levels of lipoproteins. The sexual dimorphism observed in circulating levels of measured apolipoproteins following vitamin D correction may explain, in part, known sexual disparity in the events of cardiometabolic health.

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Accepted/In Press date: 12 December 2017
e-pub ahead of print date: 14 December 2017

Identifiers

Local EPrints ID: 418900
URI: http://eprints.soton.ac.uk/id/eprint/418900
ISSN: 0960-0760
PURE UUID: 82e133fe-9563-456a-92f9-f984575dce35
ORCID for Spiros Garbis: ORCID iD orcid.org/0000-0002-1050-0805

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Date deposited: 23 Mar 2018 17:31
Last modified: 20 Jul 2019 00:45

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