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Association of oily fish intake, sex, age, BMI, and APOE genotype with plasma long chain n-3 fatty acid composition

Association of oily fish intake, sex, age, BMI, and APOE genotype with plasma long chain n-3 fatty acid composition
Association of oily fish intake, sex, age, BMI, and APOE genotype with plasma long chain n-3 fatty acid composition
n-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and APOE genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to APOE genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (P≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (P≤0·034). DPA was higher in TAG in males than females (P<0·001). There was a positive association between BMI and DPA and DHA in TAG (P<0·006 and 0·02, respectively). APOE genotype×sex interactions were observed: the APOE4 allele associated with higher EPA in males (P=0·002), and there was also evidence for higher DPA and DHA (P≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and APOE genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.
0007-1145
23-32
Fisk, Helena L.
2483d346-75dd-41b3-a481-10f8bb39cd9f
Irvine, Michael
49733d3a-ef73-47fd-b212-6a32c09f2081
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Mathers, John C.
1d611724-153d-4088-8ed8-b0a339355f3d
Packard, Chris J.
26d125eb-2168-461f-8f94-27a044779b43
Armah, Christopher K.
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Kofler, Bettina M.
dd925b7b-936c-4233-9742-e64137ca53fc
Curtis, Peter J.
34e474fa-3ae5-4547-be0a-fee4d9743f96
Minihane, Anne M.
7fa08df7-b5a5-4c73-83c5-4ad61443ff88
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Fisk, Helena L.
2483d346-75dd-41b3-a481-10f8bb39cd9f
Irvine, Michael
49733d3a-ef73-47fd-b212-6a32c09f2081
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Mathers, John C.
1d611724-153d-4088-8ed8-b0a339355f3d
Packard, Chris J.
26d125eb-2168-461f-8f94-27a044779b43
Armah, Christopher K.
3caff004-6236-4e59-85c0-21873ce623bd
Kofler, Bettina M.
dd925b7b-936c-4233-9742-e64137ca53fc
Curtis, Peter J.
34e474fa-3ae5-4547-be0a-fee4d9743f96
Minihane, Anne M.
7fa08df7-b5a5-4c73-83c5-4ad61443ff88
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Fisk, Helena L., Irvine, Michael, Miles, Elizabeth A., Mathers, John C., Packard, Chris J., Armah, Christopher K., Kofler, Bettina M., Curtis, Peter J., Minihane, Anne M. and Calder, Philip C. (2018) Association of oily fish intake, sex, age, BMI, and APOE genotype with plasma long chain n-3 fatty acid composition. British Journal of Nutrition, 120 (1), 23-32. (doi:10.1017/S000711451800106X).

Record type: Article

Abstract

n-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and APOE genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to APOE genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (P≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (P≤0·034). DPA was higher in TAG in males than females (P<0·001). There was a positive association between BMI and DPA and DHA in TAG (P<0·006 and 0·02, respectively). APOE genotype×sex interactions were observed: the APOE4 allele associated with higher EPA in males (P=0·002), and there was also evidence for higher DPA and DHA (P≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and APOE genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.

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Effect of Oily Fish Intake Sex Age BMI and APOE genotype on Plasma LC n3 Fatty Acid - Accepted Manuscript
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More information

Accepted/In Press date: 20 March 2018
e-pub ahead of print date: 6 May 2018
Published date: 1 July 2018

Identifiers

Local EPrints ID: 418975
URI: http://eprints.soton.ac.uk/id/eprint/418975
ISSN: 0007-1145
PURE UUID: 6da8a893-d6a3-460a-ae58-4424c692bf38
ORCID for Helena L. Fisk: ORCID iD orcid.org/0000-0002-9534-3246
ORCID for Elizabeth A. Miles: ORCID iD orcid.org/0000-0002-8643-0655
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 27 Mar 2018 16:30
Last modified: 22 Nov 2021 06:14

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Contributors

Author: Helena L. Fisk ORCID iD
Author: Michael Irvine
Author: John C. Mathers
Author: Chris J. Packard
Author: Christopher K. Armah
Author: Bettina M. Kofler
Author: Peter J. Curtis
Author: Anne M. Minihane

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