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Separating the coherence transfer from chemical shift evolution in high-resolution Pure Shift COSY NMR

Separating the coherence transfer from chemical shift evolution in high-resolution Pure Shift COSY NMR
Separating the coherence transfer from chemical shift evolution in high-resolution Pure Shift COSY NMR
Recent developments in data sampling and processing techniques have made it possible to acquire two-dimensional NMR spectra of small molecules at digital resolutions in both dimensions approaching the intrinsic limitations of the equipment and sample on a realistic timescale. These developments offer the possibility of enormously increased effective resolution (peak dispersion) and the ability to effectively study samples where peak overlap was previously a limiting factor. Examples of such spectra have been produced for a number of two-dimensional techniques including TOCSY and HSQC. In this paper we investigate some of the problems in applying such techniques to COSY spectra, and suggest a modification to the classic experiment that alleviates some of these problems.
969-975
Aguilar, Juan A.
1436760f-c7d6-4d14-820e-7cf9b6164b55
Belda, Raquel
a049e28f-4497-4ac1-8186-efef72651cb7
Gaunt, Benjamin R.
82fee1d8-9490-4962-a665-6301a26a94e7
Kenwright, Alan M.
e296cc0d-4649-4ce2-9076-e9e0a0e76e73
Kuprov, Ilya
bb07f28a-5038-4524-8146-e3fc8344c065
Aguilar, Juan A.
1436760f-c7d6-4d14-820e-7cf9b6164b55
Belda, Raquel
a049e28f-4497-4ac1-8186-efef72651cb7
Gaunt, Benjamin R.
82fee1d8-9490-4962-a665-6301a26a94e7
Kenwright, Alan M.
e296cc0d-4649-4ce2-9076-e9e0a0e76e73
Kuprov, Ilya
bb07f28a-5038-4524-8146-e3fc8344c065

Aguilar, Juan A., Belda, Raquel, Gaunt, Benjamin R., Kenwright, Alan M. and Kuprov, Ilya (2018) Separating the coherence transfer from chemical shift evolution in high-resolution Pure Shift COSY NMR. Magnetic Resonance in Chemistry, 56 (10), 969-975. (doi:10.1002/mrc.4727).

Record type: Article

Abstract

Recent developments in data sampling and processing techniques have made it possible to acquire two-dimensional NMR spectra of small molecules at digital resolutions in both dimensions approaching the intrinsic limitations of the equipment and sample on a realistic timescale. These developments offer the possibility of enormously increased effective resolution (peak dispersion) and the ability to effectively study samples where peak overlap was previously a limiting factor. Examples of such spectra have been produced for a number of two-dimensional techniques including TOCSY and HSQC. In this paper we investigate some of the problems in applying such techniques to COSY spectra, and suggest a modification to the classic experiment that alleviates some of these problems.

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Accepted/In Press date: 8 March 2018
e-pub ahead of print date: 8 March 2018
Published date: October 2018

Identifiers

Local EPrints ID: 419031
URI: https://eprints.soton.ac.uk/id/eprint/419031
PURE UUID: 9dad7d95-bfd2-4e76-aec3-10ec540c0f16
ORCID for Ilya Kuprov: ORCID iD orcid.org/0000-0003-0430-2682

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Date deposited: 28 Mar 2018 16:30
Last modified: 14 Mar 2019 05:10

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