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Pathological nature of renal tumors - does size matter?

Pathological nature of renal tumors - does size matter?
Pathological nature of renal tumors - does size matter?

Introduction: We examined the relationship between the size and nature of renal masses in term of malignant potential, histological grading, pathological staging and presence of necrosis and sarcomatoid changes.

Materials and Methods: Retrospectively, we reviewed 323 consecutive nephrectomies between 2000 and 2010. Final pathology was correlated with tumour size. The renal tumours were stratified into three groups according to the largest diameter, defined as 4 cm or smaller, greater than 4 cm to 7 cm, and greater than 7 cm. We recorded the proportion of benign tumours, tumour grade and stage, presence of necrosis and sarcomatoid change.

Results: Small renal masses ≤4 cm (SRMs) were more likely to be localised to the kidney (90%) and of lower histological grade (75%). The proportion of benign tumours in SRMs (15%) was higher than other two groups with the majority of benign tumours being oncocytomas. There was a statistically significant trend with greater necrosis and sarcomatoid change for the large size group.

Conclusions: SRMs are likely to be low grade and organ confined with little or no adverse pathological features. There is increased likelihood of benignity in SRTs with the majority of benign tumours being oncocytomas.

Journal Article
2090-5998
330-334
Kurban, Lutfi Ali S.
d2efc878-e91d-4e33-bb23-ea70b72abdd0
Vosough, Alireza
77052cd0-1a90-4f86-9937-b09a2e9de764
Jacob, Preman
500af54e-1aef-48d7-bfab-3337faba4187
Prasad, Deepak
1084092a-e523-4b49-a2e8-df62098ce220
Lam, Thomas
61f506bc-674c-4a03-ab87-fb60c8ae77d1
Scott, Neil
489dd3d9-eede-4bb6-9c58-6ef12428d526
Somani, Bhaskar K.
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Kurban, Lutfi Ali S.
d2efc878-e91d-4e33-bb23-ea70b72abdd0
Vosough, Alireza
77052cd0-1a90-4f86-9937-b09a2e9de764
Jacob, Preman
500af54e-1aef-48d7-bfab-3337faba4187
Prasad, Deepak
1084092a-e523-4b49-a2e8-df62098ce220
Lam, Thomas
61f506bc-674c-4a03-ab87-fb60c8ae77d1
Scott, Neil
489dd3d9-eede-4bb6-9c58-6ef12428d526
Somani, Bhaskar K.
ab5fd1ce-02df-4b88-b25e-8ece396335d9

Kurban, Lutfi Ali S., Vosough, Alireza, Jacob, Preman, Prasad, Deepak, Lam, Thomas, Scott, Neil and Somani, Bhaskar K. (2017) Pathological nature of renal tumors - does size matter? Arab Journal of Urology, 9 (4), 330-334. (doi:10.4103/UA.UA_17_17).

Record type: Article

Abstract

Introduction: We examined the relationship between the size and nature of renal masses in term of malignant potential, histological grading, pathological staging and presence of necrosis and sarcomatoid changes.

Materials and Methods: Retrospectively, we reviewed 323 consecutive nephrectomies between 2000 and 2010. Final pathology was correlated with tumour size. The renal tumours were stratified into three groups according to the largest diameter, defined as 4 cm or smaller, greater than 4 cm to 7 cm, and greater than 7 cm. We recorded the proportion of benign tumours, tumour grade and stage, presence of necrosis and sarcomatoid change.

Results: Small renal masses ≤4 cm (SRMs) were more likely to be localised to the kidney (90%) and of lower histological grade (75%). The proportion of benign tumours in SRMs (15%) was higher than other two groups with the majority of benign tumours being oncocytomas. There was a statistically significant trend with greater necrosis and sarcomatoid change for the large size group.

Conclusions: SRMs are likely to be low grade and organ confined with little or no adverse pathological features. There is increased likelihood of benignity in SRTs with the majority of benign tumours being oncocytomas.

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Accepted/In Press date: 8 June 2017
e-pub ahead of print date: 10 October 2017
Published date: 10 November 2017
Keywords: Journal Article

Identifiers

Local EPrints ID: 419094
URI: http://eprints.soton.ac.uk/id/eprint/419094
ISSN: 2090-5998
PURE UUID: 23dd46b4-cc74-4b80-bfa5-6ae808c1db64

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Date deposited: 29 Mar 2018 16:30
Last modified: 15 Mar 2024 19:01

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Contributors

Author: Lutfi Ali S. Kurban
Author: Alireza Vosough
Author: Preman Jacob
Author: Deepak Prasad
Author: Thomas Lam
Author: Neil Scott

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