Thyroid paraganglionoma
Thyroid paraganglionoma
Paraganglionoma of the thyroid is an extremely rare tumour, with fewer than thirty cases reported in the literature. These tumours are believed to arise from the inferior laryngeal paraganglia and are most common in females of middle age. Approximately 30% of head and neck paraganglionomas are hereditary, most frequently due to germline mutations in the succinate dehydrogenase gene family, but also in association with disorders including multiple endocrine neoplasia and von-Hippel-Lindau disease. This entity is frequently mistaken for other lesions, including secondary neuroendocrine tumours and follicular neoplasm. Treatment is by total thyroidectomy, or lobectomy for a solitary lesion. Despite the presence of atypical features, malignant transformation of these tumours has not been observed, with no reported recurrences following resection.
Neck mass, Paraganglionoma, Thyroid
124-125
Waise, Sara
13f667c5-853e-4120-a2c6-bbc8324e3b2a
Jogai, Sanjay
18c2f36b-4572-46d5-b17d-a6d2cdaa916c
March 2018
Waise, Sara
13f667c5-853e-4120-a2c6-bbc8324e3b2a
Jogai, Sanjay
18c2f36b-4572-46d5-b17d-a6d2cdaa916c
Abstract
Paraganglionoma of the thyroid is an extremely rare tumour, with fewer than thirty cases reported in the literature. These tumours are believed to arise from the inferior laryngeal paraganglia and are most common in females of middle age. Approximately 30% of head and neck paraganglionomas are hereditary, most frequently due to germline mutations in the succinate dehydrogenase gene family, but also in association with disorders including multiple endocrine neoplasia and von-Hippel-Lindau disease. This entity is frequently mistaken for other lesions, including secondary neuroendocrine tumours and follicular neoplasm. Treatment is by total thyroidectomy, or lobectomy for a solitary lesion. Despite the presence of atypical features, malignant transformation of these tumours has not been observed, with no reported recurrences following resection.
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Thyroid paraganglionoma
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Thyroid paraganglionoma
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Accepted/In Press date: 5 March 2018
e-pub ahead of print date: 7 March 2018
Published date: March 2018
Keywords:
Neck mass, Paraganglionoma, Thyroid
Identifiers
Local EPrints ID: 419099
URI: http://eprints.soton.ac.uk/id/eprint/419099
ISSN: 1756-2317
PURE UUID: d83c901d-9e29-486c-95dc-39140a46a203
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Date deposited: 29 Mar 2018 16:30
Last modified: 16 Mar 2024 06:23
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Author:
Sara Waise
Author:
Sanjay Jogai
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