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Thyroid paraganglionoma

Thyroid paraganglionoma
Thyroid paraganglionoma

Paraganglionoma of the thyroid is an extremely rare tumour, with fewer than thirty cases reported in the literature. These tumours are believed to arise from the inferior laryngeal paraganglia and are most common in females of middle age. Approximately 30% of head and neck paraganglionomas are hereditary, most frequently due to germline mutations in the succinate dehydrogenase gene family, but also in association with disorders including multiple endocrine neoplasia and von-Hippel-Lindau disease. This entity is frequently mistaken for other lesions, including secondary neuroendocrine tumours and follicular neoplasm. Treatment is by total thyroidectomy, or lobectomy for a solitary lesion. Despite the presence of atypical features, malignant transformation of these tumours has not been observed, with no reported recurrences following resection.

Neck mass, Paraganglionoma, Thyroid
1756-2317
124-125
Waise, Sara
13f667c5-853e-4120-a2c6-bbc8324e3b2a
Jogai, Sanjay
18c2f36b-4572-46d5-b17d-a6d2cdaa916c
Waise, Sara
13f667c5-853e-4120-a2c6-bbc8324e3b2a
Jogai, Sanjay
18c2f36b-4572-46d5-b17d-a6d2cdaa916c

Waise, Sara and Jogai, Sanjay (2018) Thyroid paraganglionoma. Diagnostic Histopathology, 24 (3), 124-125. (doi:10.1016/j.mpdhp.2018.02.005).

Record type: Article

Abstract

Paraganglionoma of the thyroid is an extremely rare tumour, with fewer than thirty cases reported in the literature. These tumours are believed to arise from the inferior laryngeal paraganglia and are most common in females of middle age. Approximately 30% of head and neck paraganglionomas are hereditary, most frequently due to germline mutations in the succinate dehydrogenase gene family, but also in association with disorders including multiple endocrine neoplasia and von-Hippel-Lindau disease. This entity is frequently mistaken for other lesions, including secondary neuroendocrine tumours and follicular neoplasm. Treatment is by total thyroidectomy, or lobectomy for a solitary lesion. Despite the presence of atypical features, malignant transformation of these tumours has not been observed, with no reported recurrences following resection.

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Accepted/In Press date: 5 March 2018
e-pub ahead of print date: 7 March 2018
Published date: March 2018
Keywords: Neck mass, Paraganglionoma, Thyroid

Identifiers

Local EPrints ID: 419099
URI: https://eprints.soton.ac.uk/id/eprint/419099
ISSN: 1756-2317
PURE UUID: d83c901d-9e29-486c-95dc-39140a46a203

Catalogue record

Date deposited: 29 Mar 2018 16:30
Last modified: 14 Mar 2019 05:10

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Contributors

Author: Sara Waise
Author: Sanjay Jogai

University divisions

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