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Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma

Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma
Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma
Introduction: Instillation of Mitomycin C (MMC) should prevent implantation of cancer cells released during endoscopic treatment and prevent recurrences as seen in carcinoma of the bladder.
Aim: To develop and evaluate a protocol for a single dose MMC instillation following Holmium: YAG laser ablation of upper urinary tract transitional cell carcinoma (UUT-TCC).
Setting and Design: A single institute prospective study.
Materials and Methods: MMC instillations protocol was designed and offered to patients between August 2005 and April 2011. Following tumor ablation, MMC was instilled into upper urinary tract (UUT) over 40 minutes. All the patients were regularly followed up.
Results: Twenty UUT units (19 patients) were managed for UUT-TCCs using our MMC protocol. Two UUT units had G1pTa tumors, 14 had G2pTa, 2 had G3pTa, and 2 had G3pT1. At a mean follow-up of 24 months (range 1-72 months), 13/20 (65%) of the UUT units remained cancer-free, 3 (15%) UUT units developed stricture and were treated with endoscopic dilatation, only 1 (5%) of these developed long-term complications. None of the patients developed postoperative renal impairment or systemic side-effects.
Conclusions: Using a set standard protocol, MMC can safely be instilled into the UUT after TCC ablation with minimal complications or side effects, good preservation of renal function, and with a low recurrences rate comparable to the literature.
Journal Article
2090-5998
184-189
Aboumarzouk, Omar M
3c7e2433-638d-4378-9931-902fdc68acce
Somani, Bhaskar
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Ahmad, Sarfraz
b8a17e16-b4d2-40ed-a502-081ec868f928
Nabi, Ghulam
20d3e635-ec9c-4b53-8703-f50b443196da
Townell, Nicholas
944f22fa-52ba-4f1a-90b8-e5cbc85bf91d
Kata, Slawomir G
bb011d0d-01f0-4c99-ac40-e8db8d4ef4d0
Aboumarzouk, Omar M
3c7e2433-638d-4378-9931-902fdc68acce
Somani, Bhaskar
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Ahmad, Sarfraz
b8a17e16-b4d2-40ed-a502-081ec868f928
Nabi, Ghulam
20d3e635-ec9c-4b53-8703-f50b443196da
Townell, Nicholas
944f22fa-52ba-4f1a-90b8-e5cbc85bf91d
Kata, Slawomir G
bb011d0d-01f0-4c99-ac40-e8db8d4ef4d0

Aboumarzouk, Omar M, Somani, Bhaskar, Ahmad, Sarfraz, Nabi, Ghulam, Townell, Nicholas and Kata, Slawomir G (2013) Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma. Arab Journal of Urology, 5 (3), 184-189. (doi:10.4103/0974-7796.115746).

Record type: Article

Abstract

Introduction: Instillation of Mitomycin C (MMC) should prevent implantation of cancer cells released during endoscopic treatment and prevent recurrences as seen in carcinoma of the bladder.
Aim: To develop and evaluate a protocol for a single dose MMC instillation following Holmium: YAG laser ablation of upper urinary tract transitional cell carcinoma (UUT-TCC).
Setting and Design: A single institute prospective study.
Materials and Methods: MMC instillations protocol was designed and offered to patients between August 2005 and April 2011. Following tumor ablation, MMC was instilled into upper urinary tract (UUT) over 40 minutes. All the patients were regularly followed up.
Results: Twenty UUT units (19 patients) were managed for UUT-TCCs using our MMC protocol. Two UUT units had G1pTa tumors, 14 had G2pTa, 2 had G3pTa, and 2 had G3pT1. At a mean follow-up of 24 months (range 1-72 months), 13/20 (65%) of the UUT units remained cancer-free, 3 (15%) UUT units developed stricture and were treated with endoscopic dilatation, only 1 (5%) of these developed long-term complications. None of the patients developed postoperative renal impairment or systemic side-effects.
Conclusions: Using a set standard protocol, MMC can safely be instilled into the UUT after TCC ablation with minimal complications or side effects, good preservation of renal function, and with a low recurrences rate comparable to the literature.

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More information

Accepted/In Press date: 22 May 2012
e-pub ahead of print date: 29 July 2013
Published date: July 2013
Keywords: Journal Article

Identifiers

Local EPrints ID: 419110
URI: https://eprints.soton.ac.uk/id/eprint/419110
ISSN: 2090-5998
PURE UUID: 0e22d1a8-c534-42b4-9816-4b81d88a4a24

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Date deposited: 05 Apr 2018 16:30
Last modified: 13 Mar 2019 18:44

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