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Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin

Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin
Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin

A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.

alkaloids, biomass, cancer, shell biorefinery, sustainable synthesis
1864-5631
532-535
Sadiq, Alejandro D.
fd485846-b43c-46d9-9ce4-13ffdbb118cd
Chen, Xi
b3f41cd9-57e0-48e3-8a1c-f9bdf7367742
Yan, Ning
969b55e9-81e4-4930-9929-dce7cd5fb173
Sperry, Jonathan
08c6f424-99db-4aeb-a009-85494643ffdb
Sadiq, Alejandro D.
fd485846-b43c-46d9-9ce4-13ffdbb118cd
Chen, Xi
b3f41cd9-57e0-48e3-8a1c-f9bdf7367742
Yan, Ning
969b55e9-81e4-4930-9929-dce7cd5fb173
Sperry, Jonathan
08c6f424-99db-4aeb-a009-85494643ffdb

Sadiq, Alejandro D., Chen, Xi, Yan, Ning and Sperry, Jonathan (2018) Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin. ChemSusChem, 11 (3), 532-535. (doi:10.1002/cssc.201702356).

Record type: Article

Abstract

A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.

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More information

e-pub ahead of print date: 5 January 2018
Published date: 9 February 2018
Keywords: alkaloids, biomass, cancer, shell biorefinery, sustainable synthesis

Identifiers

Local EPrints ID: 419181
URI: http://eprints.soton.ac.uk/id/eprint/419181
ISSN: 1864-5631
PURE UUID: 17bdf0c0-a2ec-4b31-a70e-eb5e1a6f421f

Catalogue record

Date deposited: 06 Apr 2018 16:30
Last modified: 05 Jun 2024 17:32

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Contributors

Author: Alejandro D. Sadiq
Author: Xi Chen
Author: Ning Yan
Author: Jonathan Sperry

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