Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin

Sadiq, Alejandro D., Chen, Xi, Yan, Ning and Sperry, Jonathan (2018) Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin. ChemSusChem, 11 (3), 532-535. (doi:10.1002/cssc.201702356).

Record type: Article

Abstract

A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.

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e-pub ahead of print date: 5 January 2018

Published date: 9 February 2018

Keywords: alkaloids, biomass, cancer, shell biorefinery, sustainable synthesis

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Identifiers

Local EPrints ID: 419181

URI: http://eprints.soton.ac.uk/id/eprint/419181

DOI: doi:10.1002/cssc.201702356

ISSN: 1864-5631

PURE UUID: 17bdf0c0-a2ec-4b31-a70e-eb5e1a6f421f

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Date deposited: 06 Apr 2018 16:30

Last modified: 17 Mar 2024 11:59

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Contributors

Author: Alejandro D. Sadiq

Author: Xi Chen

Author: Ning Yan

Author: Jonathan Sperry

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