The University of Southampton
University of Southampton Institutional Repository

Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin

Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin
Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin

A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.

alkaloids, biomass, cancer, shell biorefinery, sustainable synthesis
1864-5631
532-535
Sadiq, Alejandro D.
fd485846-b43c-46d9-9ce4-13ffdbb118cd
Chen, Xi
b3f41cd9-57e0-48e3-8a1c-f9bdf7367742
Yan, Ning
969b55e9-81e4-4930-9929-dce7cd5fb173
Sperry, Jonathan
08c6f424-99db-4aeb-a009-85494643ffdb
Sadiq, Alejandro D.
fd485846-b43c-46d9-9ce4-13ffdbb118cd
Chen, Xi
b3f41cd9-57e0-48e3-8a1c-f9bdf7367742
Yan, Ning
969b55e9-81e4-4930-9929-dce7cd5fb173
Sperry, Jonathan
08c6f424-99db-4aeb-a009-85494643ffdb

Sadiq, Alejandro D., Chen, Xi, Yan, Ning and Sperry, Jonathan (2018) Towards the shell biorefinery: sustainable synthesis of the anticancer alkaloid Proximicin A from chitin. ChemSusChem, 11 (3), 532-535. (doi:10.1002/cssc.201702356).

Record type: Article

Abstract

A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.

Full text not available from this repository.

More information

e-pub ahead of print date: 5 January 2018
Published date: 9 February 2018
Keywords: alkaloids, biomass, cancer, shell biorefinery, sustainable synthesis

Identifiers

Local EPrints ID: 419181
URI: http://eprints.soton.ac.uk/id/eprint/419181
ISSN: 1864-5631
PURE UUID: 17bdf0c0-a2ec-4b31-a70e-eb5e1a6f421f

Catalogue record

Date deposited: 06 Apr 2018 16:30
Last modified: 14 Sep 2021 19:18

Export record

Altmetrics

Contributors

Author: Alejandro D. Sadiq
Author: Xi Chen
Author: Ning Yan
Author: Jonathan Sperry

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×