Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study
Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study
Background:
Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.
Methods:
We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.
Results:
Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01–1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01–1.11) and borderline (pOR = 1.15; 95% CI: 1.02–1.29) tumours.
Conclusions:
Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Dixon-Suen, Suzanne C.
d3336826-4358-463e-bd10-618350707873
on behalf of the Ovarian Cancer Association Consortium
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Dixon-Suen, Suzanne C.
d3336826-4358-463e-bd10-618350707873
Dixon-Suen, Suzanne C.
,
et al. and on behalf of the Ovarian Cancer Association Consortium
(2018)
Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
British Journal of Cancer.
(doi:10.1038/s41416-018-0011-3).
Abstract
Background:
Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.
Methods:
We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.
Results:
Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01–1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01–1.11) and borderline (pOR = 1.15; 95% CI: 1.02–1.29) tumours.
Conclusions:
Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.
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Accepted/In Press date: 9 January 2018
e-pub ahead of print date: 20 March 2018
Identifiers
Local EPrints ID: 419231
URI: http://eprints.soton.ac.uk/id/eprint/419231
ISSN: 0007-0920
PURE UUID: 00638f56-25af-4f2b-868a-4a42a3285bbc
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Date deposited: 09 Apr 2018 16:30
Last modified: 16 Mar 2024 02:39
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Author:
Suzanne C. Dixon-Suen
Corporate Author: et al.
Corporate Author: on behalf of the Ovarian Cancer Association Consortium
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