The University of Southampton
University of Southampton Institutional Repository

Photodynamic diagnostic ureterorenoscopy: a valuable tool in the detection of upper urinary tract tumour

Photodynamic diagnostic ureterorenoscopy: a valuable tool in the detection of upper urinary tract tumour
Photodynamic diagnostic ureterorenoscopy: a valuable tool in the detection of upper urinary tract tumour
Background: photodynamic diagnosis increases the detection rate and hence decreases recurrence rates of urothelial cancer (UC) of the bladder. This technique has been implemented in the upper urinary tract and like in the bladder, has shown to increase the detection rate of urothelial lesions.Objectives: to determine the sensitivity, specificity, and detection rates for photodynamic diagnostic flexible ureterorenoscopy (PDD-FURS) and white light ureterorenoscopy (WL-FURS).

Design: between 2009 and 2013, PDD-FURS was performed within 106 Upper urinary tract (UUT) Units (Mean age—72.6 ± 9.5). Indications for the procedure included abnormal upper urinary tract on imaging, normal flexible cystoscopy with abnormal urine cytology, endoscopic treatment and follow-up of UUT UC. Oral 5-aminolevulinic acid was used as the photosensitizer administered 3-4 h pre-operatively.

Results: 48 lesions were detected, of which 95.8% (46/48) where visualised by PDD-FURS compared to 47.9% (23/48) shown by WL-FURS (P < 0.0001). PDD-FURS detected significantly more carcinoma in situ (CIS) or dysplasia lesions than WL-FURS (93.75% (15/16) vs. 18.75% (3/16), respectively, (P = 0.0006)). Furthermore, PDD-FURS detected significantly more UC lesions than WL-FURS (96.9% (31/32) vs. 62.5% (20/32) (P = 0.007)).

PDD-FURS was more sensitive (95.8; range: 85.7–99.5) than WL-FURS (53.5; range: 37.7–68.8) in detecting UUT-UC (P < 0.0001). There was no difference (P = 0.716) in the specificity between PDD-FURS (96.6; range: 88.1–99.6) and WL-FURS (95.2; range: 86.7–99).

Conclusions: our results PDD-FURS with oral 5-ALA as photosensitizer suggest higher sensitivity and detection rate of urothelial tumours than WL-FURS, with a good safety profile. In our series, PDD-FURS enhanced the visualisation of flat lesions, such as CIS and dysplasia that otherwise would have been missed.
Administration, Oral, Aminolevulinic Acid, Image Enhancement, Kidney Neoplasms, Photosensitizing Agents, Reproducibility of Results, Sensitivity and Specificity, Ureteroscopy, Urethral Neoplasms, Journal Article
1572-1000
255-260
Kata, Slawomir G
bb011d0d-01f0-4c99-ac40-e8db8d4ef4d0
Aboumarzouk, Omar M
3c7e2433-638d-4378-9931-902fdc68acce
Zreik, Abdullah
d3bd6be1-c5a4-4e78-aaaa-62160c502047
Somani, Bhaskar
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Ahmad, Sarfraz
b8a17e16-b4d2-40ed-a502-081ec868f928
Nabi, Ghulam
20d3e635-ec9c-4b53-8703-f50b443196da
Buist, Ronald
d83f6881-cb69-435c-899c-b349d57c77a9
Goodman, Carol
9fada409-be5d-4d5b-8a38-6a70d3710144
Chlosta, Piotr
922ceecf-17a8-49ca-b484-8c0b5d03e70e
Golabek, Tomasz
2aa2f021-dad4-432a-84fa-c10b76117908
Moseley, Harry
d4113f63-0303-4a8b-835e-f32ebe706dd2
Kata, Slawomir G
bb011d0d-01f0-4c99-ac40-e8db8d4ef4d0
Aboumarzouk, Omar M
3c7e2433-638d-4378-9931-902fdc68acce
Zreik, Abdullah
d3bd6be1-c5a4-4e78-aaaa-62160c502047
Somani, Bhaskar
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Ahmad, Sarfraz
b8a17e16-b4d2-40ed-a502-081ec868f928
Nabi, Ghulam
20d3e635-ec9c-4b53-8703-f50b443196da
Buist, Ronald
d83f6881-cb69-435c-899c-b349d57c77a9
Goodman, Carol
9fada409-be5d-4d5b-8a38-6a70d3710144
Chlosta, Piotr
922ceecf-17a8-49ca-b484-8c0b5d03e70e
Golabek, Tomasz
2aa2f021-dad4-432a-84fa-c10b76117908
Moseley, Harry
d4113f63-0303-4a8b-835e-f32ebe706dd2

Kata, Slawomir G, Aboumarzouk, Omar M, Zreik, Abdullah, Somani, Bhaskar, Ahmad, Sarfraz, Nabi, Ghulam, Buist, Ronald, Goodman, Carol, Chlosta, Piotr, Golabek, Tomasz and Moseley, Harry (2016) Photodynamic diagnostic ureterorenoscopy: a valuable tool in the detection of upper urinary tract tumour. Photodiagnosis and photodynamic therapy, 13, 255-260. (doi:10.1016/j.pdpdt.2015.08.002).

Record type: Article

Abstract

Background: photodynamic diagnosis increases the detection rate and hence decreases recurrence rates of urothelial cancer (UC) of the bladder. This technique has been implemented in the upper urinary tract and like in the bladder, has shown to increase the detection rate of urothelial lesions.Objectives: to determine the sensitivity, specificity, and detection rates for photodynamic diagnostic flexible ureterorenoscopy (PDD-FURS) and white light ureterorenoscopy (WL-FURS).

Design: between 2009 and 2013, PDD-FURS was performed within 106 Upper urinary tract (UUT) Units (Mean age—72.6 ± 9.5). Indications for the procedure included abnormal upper urinary tract on imaging, normal flexible cystoscopy with abnormal urine cytology, endoscopic treatment and follow-up of UUT UC. Oral 5-aminolevulinic acid was used as the photosensitizer administered 3-4 h pre-operatively.

Results: 48 lesions were detected, of which 95.8% (46/48) where visualised by PDD-FURS compared to 47.9% (23/48) shown by WL-FURS (P < 0.0001). PDD-FURS detected significantly more carcinoma in situ (CIS) or dysplasia lesions than WL-FURS (93.75% (15/16) vs. 18.75% (3/16), respectively, (P = 0.0006)). Furthermore, PDD-FURS detected significantly more UC lesions than WL-FURS (96.9% (31/32) vs. 62.5% (20/32) (P = 0.007)).

PDD-FURS was more sensitive (95.8; range: 85.7–99.5) than WL-FURS (53.5; range: 37.7–68.8) in detecting UUT-UC (P < 0.0001). There was no difference (P = 0.716) in the specificity between PDD-FURS (96.6; range: 88.1–99.6) and WL-FURS (95.2; range: 86.7–99).

Conclusions: our results PDD-FURS with oral 5-ALA as photosensitizer suggest higher sensitivity and detection rate of urothelial tumours than WL-FURS, with a good safety profile. In our series, PDD-FURS enhanced the visualisation of flat lesions, such as CIS and dysplasia that otherwise would have been missed.

Full text not available from this repository.

More information

Published date: March 2016
Additional Information: Copyright © 2015 Elsevier B.V. All rights reserved.
Keywords: Administration, Oral, Aminolevulinic Acid, Image Enhancement, Kidney Neoplasms, Photosensitizing Agents, Reproducibility of Results, Sensitivity and Specificity, Ureteroscopy, Urethral Neoplasms, Journal Article

Identifiers

Local EPrints ID: 419243
URI: https://eprints.soton.ac.uk/id/eprint/419243
ISSN: 1572-1000
PURE UUID: b985bd00-0a34-4ac4-bd86-90ea2265cb68

Catalogue record

Date deposited: 09 Apr 2018 16:30
Last modified: 13 Mar 2019 18:44

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×