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Advanced body composition assessment: from body mass index to body composition profiling

Advanced body composition assessment: from body mass index to body composition profiling
Advanced body composition assessment: from body mass index to body composition profiling
This paper gives a brief overview of common non-invasive techniques for body composition analysis and a more in-depth review of a body composition assessment method based on fat-referenced quantitative MRI. Earlier published studies of this method are summarized, and a previously unpublished validation study, based on 4753 subjects from the UK Biobank imaging cohort, comparing the quantitative MRI method with dual-energy X-ray absorptiometry (DXA) is presented. For whole-body measurements of adipose tissue (AT) or fat and lean tissue (LT), DXA and quantitative MRIs show excellent agreement with linear correlation of 0.99 and 0.97, and coefficient of variation (CV) of 4.5 and 4.6 per cent for fat (computed from AT) and LT, respectively, but the agreement was found significantly lower for visceral adipose tissue, with a CV of >20 per cent. The additional ability of MRI to also measure muscle volumes, muscle AT infiltration and ectopic fat, in combination with rapid scanning protocols and efficient image analysis tools, makes quantitative MRI a powerful tool for advanced body composition assessment.
Borga, M.
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West, J.
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Bell, J.D.
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Harvey, N.C.
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Romu, T.
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Heymsfield, S.B.
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Dahlqvist Leinhard, O.
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Borga, M.
dd26e8b1-e44d-496e-91c6-4d317789c747
West, J.
a54f2efc-9fcf-458d-90a8-fc11b3142fd4
Bell, J.D.
bf21c08f-142f-4584-b145-bf5a3f3ee57a
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Romu, T.
2aa082e0-41b0-4cdf-954c-2ef3712d433a
Heymsfield, S.B.
2710bc2e-4aa4-465e-b98e-b48d331926de
Dahlqvist Leinhard, O.
bd2e854d-05d9-4d5a-8d72-ac0ab8852db0

Borga, M., West, J., Bell, J.D., Harvey, N.C., Romu, T., Heymsfield, S.B. and Dahlqvist Leinhard, O. (2018) Advanced body composition assessment: from body mass index to body composition profiling. Journal of Investigative Medicine. (doi:10.1136/jim-2018-000722).

Record type: Review

Abstract

This paper gives a brief overview of common non-invasive techniques for body composition analysis and a more in-depth review of a body composition assessment method based on fat-referenced quantitative MRI. Earlier published studies of this method are summarized, and a previously unpublished validation study, based on 4753 subjects from the UK Biobank imaging cohort, comparing the quantitative MRI method with dual-energy X-ray absorptiometry (DXA) is presented. For whole-body measurements of adipose tissue (AT) or fat and lean tissue (LT), DXA and quantitative MRIs show excellent agreement with linear correlation of 0.99 and 0.97, and coefficient of variation (CV) of 4.5 and 4.6 per cent for fat (computed from AT) and LT, respectively, but the agreement was found significantly lower for visceral adipose tissue, with a CV of >20 per cent. The additional ability of MRI to also measure muscle volumes, muscle AT infiltration and ectopic fat, in combination with rapid scanning protocols and efficient image analysis tools, makes quantitative MRI a powerful tool for advanced body composition assessment.

Text
JIM review Borga - revision 1 incl figures - Accepted Manuscript
Restricted to Repository staff only until 25 March 2019.
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More information

Accepted/In Press date: 8 March 2018
e-pub ahead of print date: 25 March 2018

Identifiers

Local EPrints ID: 419290
URI: https://eprints.soton.ac.uk/id/eprint/419290
PURE UUID: 8a8bc414-96fa-4633-85ca-9ed330f1dd85
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 10 Apr 2018 16:30
Last modified: 14 Mar 2019 01:43

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