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Lymphocytopenia may be a new indicator for infected obstructed kidneys secondary to urinary stone disease

Lymphocytopenia may be a new indicator for infected obstructed kidneys secondary to urinary stone disease
Lymphocytopenia may be a new indicator for infected obstructed kidneys secondary to urinary stone disease

OBJECTIVE: Infected obstructed kidney (IOK) is a urological emergency. We wanted to look at the role of serum inflammatory markers in these patients.

MATERIALS AND METHODS: Patients with IOK requiring percutaneous nephrostomy (PCN) at our university hospital were identified, and data were collected on lymphocyte count, C-reactive protein (CRP) and microbiology results.

RESULTS: Thirty-nine patients had PCN for IOK. Lymphocytopenia was seen in two-thirds of these patients. Severe lymphocytopenia was associated with a significant rise in CRP in all cases and following PCN, lymphocytopenia improved in the majority of cases.

CONCLUSIONS: Lymphocytopenia seems to be associated with the severity of infection and could be a surrogate marker on its own or in conjunction with CRP for initial diagnosis and monitoring response to treatment in patients with IOKs.

Journal Article
2090-5998
475-477
Ali, Ahmed
71a2b47d-0a71-41a9-a090-0904a7803771
Farell, Liam
f6295f2b-f43f-4106-860d-ac15efffe536
Somani, Bhaskar K.
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Ali, Ahmed
71a2b47d-0a71-41a9-a090-0904a7803771
Farell, Liam
f6295f2b-f43f-4106-860d-ac15efffe536
Somani, Bhaskar K.
ab5fd1ce-02df-4b88-b25e-8ece396335d9

Ali, Ahmed, Farell, Liam and Somani, Bhaskar K. (2015) Lymphocytopenia may be a new indicator for infected obstructed kidneys secondary to urinary stone disease. Arab Journal of Urology, 7 (4), 475-477. (doi:10.4103/0974-7796.157965).

Record type: Article

Abstract

OBJECTIVE: Infected obstructed kidney (IOK) is a urological emergency. We wanted to look at the role of serum inflammatory markers in these patients.

MATERIALS AND METHODS: Patients with IOK requiring percutaneous nephrostomy (PCN) at our university hospital were identified, and data were collected on lymphocyte count, C-reactive protein (CRP) and microbiology results.

RESULTS: Thirty-nine patients had PCN for IOK. Lymphocytopenia was seen in two-thirds of these patients. Severe lymphocytopenia was associated with a significant rise in CRP in all cases and following PCN, lymphocytopenia improved in the majority of cases.

CONCLUSIONS: Lymphocytopenia seems to be associated with the severity of infection and could be a surrogate marker on its own or in conjunction with CRP for initial diagnosis and monitoring response to treatment in patients with IOKs.

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More information

Accepted/In Press date: 29 October 2014
e-pub ahead of print date: 14 October 2015
Published date: 23 December 2015
Keywords: Journal Article

Identifiers

Local EPrints ID: 419377
URI: http://eprints.soton.ac.uk/id/eprint/419377
ISSN: 2090-5998
PURE UUID: 12cf7c8d-fa11-4697-9b3b-008f2be67efc

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Date deposited: 11 Apr 2018 16:30
Last modified: 13 Mar 2019 18:44

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Author: Ahmed Ali
Author: Liam Farell

University divisions

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