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Routine use of daily oral vitamin K to treat infants with cystic fibrosis

Routine use of daily oral vitamin K to treat infants with cystic fibrosis
Routine use of daily oral vitamin K to treat infants with cystic fibrosis

Vitamin K is routinely administered after birth in the UK to prevent haemorrhagic disease of the newborn. Despite this, vitamin K-deficient coagulopathy still occurs in infants with high morbidity and mortality. Up to 50% of late onset bleeding presents with intracranial haemorrhage. The risk of developing vitamin K coagulopathy is higher in infants with cystic fibrosis (CF) and those that are exclusively breast fed due to low vitamin K levels in breast milk and intestinal changes in bacterial flora.Oral vitamin K supplementation is a simple addition to routine CF treatment during infancy to prevent complications from significant coagulopathy.

Cystic Fibrosis, Vitamin K
1526-0542
22-24
Cottam, Sophie T.
f8fbc413-a56b-472a-95ea-a5db9496b319
Connett, Gary J.
55d5676c-90d8-46bf-a508-62eded276516
Cottam, Sophie T.
f8fbc413-a56b-472a-95ea-a5db9496b319
Connett, Gary J.
55d5676c-90d8-46bf-a508-62eded276516

Cottam, Sophie T. and Connett, Gary J. (2015) Routine use of daily oral vitamin K to treat infants with cystic fibrosis. Paediatric Respiratory Reviews, 16 (Supplement 1), 22-24, [1062]. (doi:10.1016/j.prrv.2015.07.012).

Record type: Review

Abstract

Vitamin K is routinely administered after birth in the UK to prevent haemorrhagic disease of the newborn. Despite this, vitamin K-deficient coagulopathy still occurs in infants with high morbidity and mortality. Up to 50% of late onset bleeding presents with intracranial haemorrhage. The risk of developing vitamin K coagulopathy is higher in infants with cystic fibrosis (CF) and those that are exclusively breast fed due to low vitamin K levels in breast milk and intestinal changes in bacterial flora.Oral vitamin K supplementation is a simple addition to routine CF treatment during infancy to prevent complications from significant coagulopathy.

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More information

e-pub ahead of print date: 22 September 2015
Published date: 1 October 2015
Keywords: Cystic Fibrosis, Vitamin K

Identifiers

Local EPrints ID: 419468
URI: http://eprints.soton.ac.uk/id/eprint/419468
ISSN: 1526-0542
PURE UUID: f6ba47a6-3f16-4c73-a2a4-34c8c1d4042c
ORCID for Gary J. Connett: ORCID iD orcid.org/0000-0003-1310-3239

Catalogue record

Date deposited: 12 Apr 2018 16:30
Last modified: 26 Mar 2021 02:58

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Contributors

Author: Sophie T. Cottam
Author: Gary J. Connett ORCID iD

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