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Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension

Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension
Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension
Electric fields can induce various types of motion in liquid suspensions of colloidal nanoparticles. These electrokinetic phenomena depend on the parameters of the electric field (frequency, amplitude, 3D topology), the particles (size, shape,composition) and the suspending liquid (polarizability, ionic strength, pH). In particular, the dielectrophoretic force onsubmicron colloidal particles is dependent on the properties of the electric double layer (the "ion cloud") around theseparticles. This dependence provides a mechanism for detecting and quantifying interactions between biomolecules andthese nanoparticles, which can be combined with optical and spectroscopic measurements. Here, we report onfunctionalized plasmonic nanoparticles that are tracked inside microfluidic systems by dark-field video-microscopy. Ahigh-gradient AC electric field is set up using transparent micro-electrodes. Electrohydrodynamic motion of the entirefluid and dielectrophoretic trapping of individual particles can be analyzed quantitatively by numerical methods. Byswitching the electric field synchronously with the video acquisition, the effect of biomolecules on the electrokinetictrapping can be quantified. The electromicrofluidic devices allow also for rapid measurement of diffusion coefficients.
SPIE: the International Society for Optics and Photonics
Midelet, C.
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Lin, J.-Y.
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Tsang, S.
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Sun, C.-I.
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Midelet, J.
9ead62c9-7a1c-4f84-81f3-918e3683b909
Kanaras, A.G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Le Pioufle, B.
cda73239-ea23-4e9a-9d51-31d1c09216d0
Francais, O.
87601b8b-61cf-4e8d-a166-2e5a8457a42b
Werts, M.H.V.
750f9843-296d-40e6-9ef0-75cae4a042cd
Osinski, Marek
Parak, Wolfgang J.
Liang, Xing-Jie
Midelet, C.
ae2f54a2-1016-4907-88a3-3c551ea4566d
Lin, J.-Y.
dfa937f7-d257-487e-bf61-eceac17a3ede
Tsang, S.
3f5c1cd1-87a9-4228-8aba-01d885623c11
Sun, C.-I.
0891da6f-8055-4834-965c-d5f7c3a01d87
Midelet, J.
9ead62c9-7a1c-4f84-81f3-918e3683b909
Kanaras, A.G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Le Pioufle, B.
cda73239-ea23-4e9a-9d51-31d1c09216d0
Francais, O.
87601b8b-61cf-4e8d-a166-2e5a8457a42b
Werts, M.H.V.
750f9843-296d-40e6-9ef0-75cae4a042cd
Osinski, Marek
Parak, Wolfgang J.
Liang, Xing-Jie

Midelet, C., Lin, J.-Y., Tsang, S., Sun, C.-I., Midelet, J., Kanaras, A.G., Le Pioufle, B., Francais, O. and Werts, M.H.V. (2017) Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension. Osinski, Marek, Parak, Wolfgang J. and Liang, Xing-Jie (eds.) In Colloidal Nanoparticles for Biomedical Applications XII. vol. 1007801, SPIE: the International Society for Optics and Photonics.. (doi:10.1117/12.2252470).

Record type: Conference or Workshop Item (Paper)

Abstract

Electric fields can induce various types of motion in liquid suspensions of colloidal nanoparticles. These electrokinetic phenomena depend on the parameters of the electric field (frequency, amplitude, 3D topology), the particles (size, shape,composition) and the suspending liquid (polarizability, ionic strength, pH). In particular, the dielectrophoretic force onsubmicron colloidal particles is dependent on the properties of the electric double layer (the "ion cloud") around theseparticles. This dependence provides a mechanism for detecting and quantifying interactions between biomolecules andthese nanoparticles, which can be combined with optical and spectroscopic measurements. Here, we report onfunctionalized plasmonic nanoparticles that are tracked inside microfluidic systems by dark-field video-microscopy. Ahigh-gradient AC electric field is set up using transparent micro-electrodes. Electrohydrodynamic motion of the entirefluid and dielectrophoretic trapping of individual particles can be analyzed quantitatively by numerical methods. Byswitching the electric field synchronously with the video acquisition, the effect of biomolecules on the electrokinetictrapping can be quantified. The electromicrofluidic devices allow also for rapid measurement of diffusion coefficients.

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e-pub ahead of print date: 22 February 2017
Published date: 2017

Identifiers

Local EPrints ID: 419489
URI: https://eprints.soton.ac.uk/id/eprint/419489
PURE UUID: 26cc1d99-4458-4935-b4b3-af96ff0554d8
ORCID for A.G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

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Date deposited: 12 Apr 2018 16:31
Last modified: 14 Mar 2019 01:39

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Contributors

Author: C. Midelet
Author: J.-Y. Lin
Author: S. Tsang
Author: C.-I. Sun
Author: J. Midelet
Author: A.G. Kanaras ORCID iD
Author: B. Le Pioufle
Author: O. Francais
Author: M.H.V. Werts
Editor: Marek Osinski
Editor: Wolfgang J. Parak
Editor: Xing-Jie Liang

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