A protocol for an economic evaluation of a polypill in patients with established or at high risk of cardiovascular disease in a UK NHS setting: RUPEE (NHS) study
A protocol for an economic evaluation of a polypill in patients with established or at high risk of cardiovascular disease in a UK NHS setting: RUPEE (NHS) study
Introduction: the Use of a Multi-drug Pill in Reducing cardiovascular Events' (UMPIRE) trial was a randomised controlled clinical trial evaluating the impact of a polypill strategy on adherence to indicated medication in a population with established cardiovascular disease (CVD) of or at high risk thereof. The aim of Researching the UMPIRE Processes for Economic Evaluation in the National Health Service (RUPEE NHS) is to estimate the potential health economic impact of a polypill strategy for CVD prevention within the NHS using UMPIRE trial and other relevant data. This paper describes the design of a modelled economic evaluation of the impact of increased adherence to the polypill versus usual care among the UK UMPIRE participants.
Methods and analysis: as recommended by the International Society for Pharmacoeconomics and Outcomes Research and the Society for Medical Decision Making modelling guidelines, a review of published CVD models was undertaken to identify the most appropriate modelling approach and structure. The review was carried out in the electronic databases, MEDLINE and EMBASE. 40 CVD models were identified from 57 studies, the majority of economic models were health state transition cohort models and individual-level simulation models. The findings were discussed with clinical experts to confirm the approach and structure. An individual simulation approach was identified as the most suitable method to capture the heterogeneity in the population at CVD risk. RUPEE-NHS will use UMPIRE trial data on adherence to estimate the long-term cost-effectiveness of the polypill strategy.
Dissemination: the evaluation findings will be presented in open-access scientific and healthcare policy journals and at national and international conferences. We will also present findings to NHS policy makers and pharmaceutical companies.
adherence, cardiovascular disease, cost-effectiveness, economic evaluation, polypill
Crossan, Catriona
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Dehbi, Hakim Moulay
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Williams, Hilarie
ce38282d-f6c3-4808-b493-1e189a3a1fc2
Poulter, Neil
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Rodgers, Anthony
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Jan, Stephen
2b578fde-5a66-4c92-b1cb-512366fcad63
Thom, Simon
a301c071-e5ba-4424-b92a-3ea4804e6e71
Lord, Joanne
fd3b2bf0-9403-466a-8184-9303bdc80a9a
March 2018
Crossan, Catriona
618fb461-ecd2-47da-9b50-82b136ad28b6
Dehbi, Hakim Moulay
8464d2e0-f2ac-40da-a8c4-bf6d1bbfb1de
Williams, Hilarie
ce38282d-f6c3-4808-b493-1e189a3a1fc2
Poulter, Neil
a413e065-4444-43f9-8a41-f18da58210e4
Rodgers, Anthony
c81048ab-404d-41f8-a6fc-06accdecc4d4
Jan, Stephen
2b578fde-5a66-4c92-b1cb-512366fcad63
Thom, Simon
a301c071-e5ba-4424-b92a-3ea4804e6e71
Lord, Joanne
fd3b2bf0-9403-466a-8184-9303bdc80a9a
Crossan, Catriona, Dehbi, Hakim Moulay, Williams, Hilarie, Poulter, Neil, Rodgers, Anthony, Jan, Stephen, Thom, Simon and Lord, Joanne
(2018)
A protocol for an economic evaluation of a polypill in patients with established or at high risk of cardiovascular disease in a UK NHS setting: RUPEE (NHS) study.
BMJ Open, 8 (3), [e013063].
(doi:10.1136/bmjopen-2016-013063).
Abstract
Introduction: the Use of a Multi-drug Pill in Reducing cardiovascular Events' (UMPIRE) trial was a randomised controlled clinical trial evaluating the impact of a polypill strategy on adherence to indicated medication in a population with established cardiovascular disease (CVD) of or at high risk thereof. The aim of Researching the UMPIRE Processes for Economic Evaluation in the National Health Service (RUPEE NHS) is to estimate the potential health economic impact of a polypill strategy for CVD prevention within the NHS using UMPIRE trial and other relevant data. This paper describes the design of a modelled economic evaluation of the impact of increased adherence to the polypill versus usual care among the UK UMPIRE participants.
Methods and analysis: as recommended by the International Society for Pharmacoeconomics and Outcomes Research and the Society for Medical Decision Making modelling guidelines, a review of published CVD models was undertaken to identify the most appropriate modelling approach and structure. The review was carried out in the electronic databases, MEDLINE and EMBASE. 40 CVD models were identified from 57 studies, the majority of economic models were health state transition cohort models and individual-level simulation models. The findings were discussed with clinical experts to confirm the approach and structure. An individual simulation approach was identified as the most suitable method to capture the heterogeneity in the population at CVD risk. RUPEE-NHS will use UMPIRE trial data on adherence to estimate the long-term cost-effectiveness of the polypill strategy.
Dissemination: the evaluation findings will be presented in open-access scientific and healthcare policy journals and at national and international conferences. We will also present findings to NHS policy makers and pharmaceutical companies.
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Accepted/In Press date: 12 September 2016
e-pub ahead of print date: 14 March 2018
Published date: March 2018
Keywords:
adherence, cardiovascular disease, cost-effectiveness, economic evaluation, polypill
Identifiers
Local EPrints ID: 419498
URI: http://eprints.soton.ac.uk/id/eprint/419498
ISSN: 2044-6055
PURE UUID: ad825138-4d40-4e4d-a8d2-90f2e82edafb
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Date deposited: 13 Apr 2018 16:30
Last modified: 18 Mar 2024 03:32
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Contributors
Author:
Catriona Crossan
Author:
Hakim Moulay Dehbi
Author:
Hilarie Williams
Author:
Neil Poulter
Author:
Anthony Rodgers
Author:
Stephen Jan
Author:
Simon Thom
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