Falsely elevated serum tobraycin levels in a patient receiving nebulised tobramycin
Falsely elevated serum tobraycin levels in a patient receiving nebulised tobramycin
It is common when treating patients with respiratory exacerbations of cystic fibrosis to use both nebulised and intravenous antibiotics. Aminoglycoside drug levels are often measured from finger-prick blood samples. We describe a case of a 14-year-old girl treated simultaneously with IV and nebulised tobramycin in whom drug levels, measured from finger prick blood samples, were erroneously high due to finger contamination by the nebulised drug. Special precautions or direct venepuncture is essential when assessing antibiotic levels in such patients.
Contamination, Drug levels, Tobramycin
146-147
Struthers, S.L.
af52bc0d-a7fc-4af2-9970-9193b9e04de7
Nicholson, T.
3f7061b0-5d3b-4ed3-b2de-1a50f0d5983e
Jones, G.
6f771ff0-5f71-4709-be07-8bcf83871a7c
Connett, G.J.
55d5676c-90d8-46bf-a508-62eded276516
September 2002
Struthers, S.L.
af52bc0d-a7fc-4af2-9970-9193b9e04de7
Nicholson, T.
3f7061b0-5d3b-4ed3-b2de-1a50f0d5983e
Jones, G.
6f771ff0-5f71-4709-be07-8bcf83871a7c
Connett, G.J.
55d5676c-90d8-46bf-a508-62eded276516
Struthers, S.L., Nicholson, T., Jones, G. and Connett, G.J.
(2002)
Falsely elevated serum tobraycin levels in a patient receiving nebulised tobramycin.
Journal of Cystic Fibrosis, 1 (3), .
(doi:10.1016/S1569-1993(02)00073-5).
Abstract
It is common when treating patients with respiratory exacerbations of cystic fibrosis to use both nebulised and intravenous antibiotics. Aminoglycoside drug levels are often measured from finger-prick blood samples. We describe a case of a 14-year-old girl treated simultaneously with IV and nebulised tobramycin in whom drug levels, measured from finger prick blood samples, were erroneously high due to finger contamination by the nebulised drug. Special precautions or direct venepuncture is essential when assessing antibiotic levels in such patients.
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Published date: September 2002
Keywords:
Contamination, Drug levels, Tobramycin
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Local EPrints ID: 419565
URI: http://eprints.soton.ac.uk/id/eprint/419565
ISSN: 1569-1993
PURE UUID: 375e2ac2-dfbc-4cff-a57b-dc5bdf69b92b
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Date deposited: 13 Apr 2018 16:30
Last modified: 16 Mar 2024 04:35
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Contributors
Author:
S.L. Struthers
Author:
T. Nicholson
Author:
G. Jones
Author:
G.J. Connett
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