Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis
Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis
A 16-year-old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of "whole" sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis.
Antibiotic sensitivity, Cystic fibrosis, Microbiology, Pseudomonas aeruginosa, Sputum
463-466
Serisier, David J.
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Jones, Graeme
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Tuck, Andrew
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Connett, Gary
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Carroll, Mary P.
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1 June 2003
Serisier, David J.
409cd11c-5a75-487a-a6e0-e5f66abbdf5f
Jones, Graeme
f26c7d03-cd84-40c8-ae3a-286e861a5a29
Tuck, Andrew
90d0a731-080b-4872-8fc0-45cd71db1e2c
Connett, Gary
55d5676c-90d8-46bf-a508-62eded276516
Carroll, Mary P.
b836d262-6b07-4006-9c81-26653a26588b
Serisier, David J., Jones, Graeme, Tuck, Andrew, Connett, Gary and Carroll, Mary P.
(2003)
Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis.
Pediatric Pulmonology, 35 (6), .
(doi:10.1002/ppul.10294).
Abstract
A 16-year-old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of "whole" sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis.
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e-pub ahead of print date: 8 May 2003
Published date: 1 June 2003
Keywords:
Antibiotic sensitivity, Cystic fibrosis, Microbiology, Pseudomonas aeruginosa, Sputum
Identifiers
Local EPrints ID: 419566
URI: http://eprints.soton.ac.uk/id/eprint/419566
ISSN: 8755-6863
PURE UUID: 9e7af6ef-d75b-459a-a9dd-281c21a3e5f6
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Date deposited: 13 Apr 2018 16:30
Last modified: 16 Mar 2024 04:35
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Contributors
Author:
David J. Serisier
Author:
Graeme Jones
Author:
Andrew Tuck
Author:
Gary Connett
Author:
Mary P. Carroll
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