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Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis

Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis
Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis

A 16-year-old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of "whole" sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis.

Antibiotic sensitivity, Cystic fibrosis, Microbiology, Pseudomonas aeruginosa, Sputum
8755-6863
463-466
Serisier, David J.
409cd11c-5a75-487a-a6e0-e5f66abbdf5f
Jones, Graeme
f26c7d03-cd84-40c8-ae3a-286e861a5a29
Tuck, Andrew
90d0a731-080b-4872-8fc0-45cd71db1e2c
Connett, Gary
55d5676c-90d8-46bf-a508-62eded276516
Carroll, Mary P.
b836d262-6b07-4006-9c81-26653a26588b
Serisier, David J.
409cd11c-5a75-487a-a6e0-e5f66abbdf5f
Jones, Graeme
f26c7d03-cd84-40c8-ae3a-286e861a5a29
Tuck, Andrew
90d0a731-080b-4872-8fc0-45cd71db1e2c
Connett, Gary
55d5676c-90d8-46bf-a508-62eded276516
Carroll, Mary P.
b836d262-6b07-4006-9c81-26653a26588b

Serisier, David J., Jones, Graeme, Tuck, Andrew, Connett, Gary and Carroll, Mary P. (2003) Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis. Pediatric Pulmonology, 35 (6), 463-466. (doi:10.1002/ppul.10294).

Record type: Article

Abstract

A 16-year-old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of "whole" sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis.

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More information

e-pub ahead of print date: 8 May 2003
Published date: 1 June 2003
Keywords: Antibiotic sensitivity, Cystic fibrosis, Microbiology, Pseudomonas aeruginosa, Sputum

Identifiers

Local EPrints ID: 419566
URI: http://eprints.soton.ac.uk/id/eprint/419566
ISSN: 8755-6863
PURE UUID: 9e7af6ef-d75b-459a-a9dd-281c21a3e5f6
ORCID for Gary Connett: ORCID iD orcid.org/0000-0003-1310-3239

Catalogue record

Date deposited: 13 Apr 2018 16:30
Last modified: 07 Oct 2020 02:20

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Contributors

Author: David J. Serisier
Author: Graeme Jones
Author: Andrew Tuck
Author: Gary Connett ORCID iD
Author: Mary P. Carroll

University divisions

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