Association between skirt size and chronic liver disease in post-menopausal women: a prospective cohort study within the United Kingdom Trial of Ovarian Cancer Screening (UKCTOCS)
Association between skirt size and chronic liver disease in post-menopausal women: a prospective cohort study within the United Kingdom Trial of Ovarian Cancer Screening (UKCTOCS)
Background: we investigated the association between self-reported skirt size (SS) and change in SS, and incidence of chronic liver disease (CLD) in a prospective cohort study of women recruited to the UKCTOCS trial.
Methods: women recruited to UKCTOCS in England without documented CLD self-reported their current UK SS during trial participation and were asked to recall their SS when aged in 20s (via completion of a questionnaire 3-5 years after recruitment). Participants were followed up via electronic health record linkage and hazard ratios (HR) calculated for incident liver-related events (LRE).
Results: three hundred twenty-two (0.3%) of 94,124 women experienced a first LRE. Compared to SS ≤ 16, rates of LRE were higher in the SS ≥ 18 groups (both when aged in 20s and at questionnaire completion). Event rates were higher if there was no change in SS or an increase in SS, compared to a decrease in SS. In the models adjusted for potential confounders, HRs for LRE were higher in the groups of women reporting SS ≥ 18 both when aged in 20s (HR = 1.39 (95% CI; 0.87-2.23)) and at questionnaire completion (HR = 1.37 (95% CI; 1.07-1.75)). Compared to a decrease in SS, HRs were higher in the no change (HR = 1.78 (95% CI; 0.95-3.34)) and increase (HR = 1.80 (95% CI; 1.01-3.21)) groups.
Conclusion: CLD is associated with high SS and an increase in SS over time. These data suggest SS can be used in simple public health messages about communicating the risk of liver disease. Trial Registration: UKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978. Registered 06/04/2000.
Body mass index, Chronic liver disease, Cirrhosis, Obesity, Skirt size, UKCTOCS
Trembling, P. M.
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Apostolidou, S.
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Gentry-Maharaj, A.
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Parkes, J.
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Ryan, A.
b12a335a-711b-417b-89d3-1a5b587d4292
Tanwar, S.
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Burnell, M.
54411b92-a8bc-4728-8959-a6667713cecd
Menon, U.
9b09d647-03b2-40fd-bf7f-150e7ebcb10f
Rosenberg, W. M.
145ebec3-ffb6-45e7-8711-aa520ed42f55
27 March 2018
Trembling, P. M.
28891cfb-fe47-4d3c-ab50-66966965551f
Apostolidou, S.
9face157-2a2f-4e8a-a36f-4502af001c02
Gentry-Maharaj, A.
df8f0fdd-d109-4712-a323-456c686e633e
Parkes, J.
59dc6de3-4018-415e-bb99-13552f97e984
Ryan, A.
b12a335a-711b-417b-89d3-1a5b587d4292
Tanwar, S.
4c087a17-47bc-4a07-9f0b-0550b2c14e1f
Burnell, M.
54411b92-a8bc-4728-8959-a6667713cecd
Menon, U.
9b09d647-03b2-40fd-bf7f-150e7ebcb10f
Rosenberg, W. M.
145ebec3-ffb6-45e7-8711-aa520ed42f55
Trembling, P. M., Apostolidou, S., Gentry-Maharaj, A., Parkes, J., Ryan, A., Tanwar, S., Burnell, M., Menon, U. and Rosenberg, W. M.
(2018)
Association between skirt size and chronic liver disease in post-menopausal women: a prospective cohort study within the United Kingdom Trial of Ovarian Cancer Screening (UKCTOCS).
BMC Public Health, 18 (1), [409].
(doi:10.1186/s12889-018-5308-x).
Abstract
Background: we investigated the association between self-reported skirt size (SS) and change in SS, and incidence of chronic liver disease (CLD) in a prospective cohort study of women recruited to the UKCTOCS trial.
Methods: women recruited to UKCTOCS in England without documented CLD self-reported their current UK SS during trial participation and were asked to recall their SS when aged in 20s (via completion of a questionnaire 3-5 years after recruitment). Participants were followed up via electronic health record linkage and hazard ratios (HR) calculated for incident liver-related events (LRE).
Results: three hundred twenty-two (0.3%) of 94,124 women experienced a first LRE. Compared to SS ≤ 16, rates of LRE were higher in the SS ≥ 18 groups (both when aged in 20s and at questionnaire completion). Event rates were higher if there was no change in SS or an increase in SS, compared to a decrease in SS. In the models adjusted for potential confounders, HRs for LRE were higher in the groups of women reporting SS ≥ 18 both when aged in 20s (HR = 1.39 (95% CI; 0.87-2.23)) and at questionnaire completion (HR = 1.37 (95% CI; 1.07-1.75)). Compared to a decrease in SS, HRs were higher in the no change (HR = 1.78 (95% CI; 0.95-3.34)) and increase (HR = 1.80 (95% CI; 1.01-3.21)) groups.
Conclusion: CLD is associated with high SS and an increase in SS over time. These data suggest SS can be used in simple public health messages about communicating the risk of liver disease. Trial Registration: UKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978. Registered 06/04/2000.
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skirt size liver disease
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Accepted/In Press date: 13 March 2018
e-pub ahead of print date: 27 March 2018
Published date: 27 March 2018
Keywords:
Body mass index, Chronic liver disease, Cirrhosis, Obesity, Skirt size, UKCTOCS
Identifiers
Local EPrints ID: 419621
URI: http://eprints.soton.ac.uk/id/eprint/419621
ISSN: 1471-2458
PURE UUID: 03bb7004-58e3-4081-84f1-73eed2263d95
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Date deposited: 16 Apr 2018 16:30
Last modified: 16 Mar 2024 03:02
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Contributors
Author:
P. M. Trembling
Author:
S. Apostolidou
Author:
A. Gentry-Maharaj
Author:
A. Ryan
Author:
S. Tanwar
Author:
M. Burnell
Author:
U. Menon
Author:
W. M. Rosenberg
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