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Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder, and methamphetamine-induced psychotic disorder

Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder, and methamphetamine-induced psychotic disorder
Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder, and methamphetamine-induced psychotic disorder
Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. It is known that increased delta and decreased alpha, which are apparent in psychosis, are indicative of inappropriate arousal state, which leads to reduced ability to attend to relevant information. On this premise, we investigated delta/alpha frequency activity, as this ratio of frequency activity may serve as an effective neurophysiological biomarker. The current study investigated differences in delta/alpha frequency activity, in schizophrenia (SCZ), bipolar I disorder with psychotic features and methamphetamine-induced psychosis. One hundred and nine participants, including individuals with SCZ (n = 28), bipolar I disorder with psychotic features (n = 28), methamphetamine-induced psychotic disorder (MPD) (n = 24) and healthy controls (CON, n = 29). Diagnosis was ascertained with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition disorders and current medication was recorded. EEG was undertaken in three testing conditions: resting eyes open, resting eyes closed and during completion of a simple cognitive task (visual continuous performance task). EEG delta/alpha frequency activity was investigated across these conditions. First, delta/alpha frequency activity during resting eyes closed was higher in SCZ and MPD globally, when compared to CON, then lower for bipolar disorder (BPD) than MPD for right hemisphere. Second, delta/alpha frequency activity during resting eyes open was higher in SCZ, BPD and MPD for all electrodes, except left frontal, when compared to CON. Third, delta/alpha frequency activity during the cognitive task was higher in BPD and MPD for all electrodes, except left frontal, when compared to CON. Assessment of EEG delta/alpha frequency activity supports the delineation of underlying neurophysiological mechanisms present in psychotic disorders, which are likely related to dysfunctional thalamo-cortical connectivity. Delta/alpha frequency activity may provide a useful neurophysiological biomarker to delineate psychotic disorders.
delta, alpha, biomarker, psychosis, EEG, methamphetamine
1-11
Howells, Fleur M.
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Temmingh, Hendrik S.
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Hsieh, Jennifer H.
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van Dijen, Andrea V.
b9ece84d-1ef8-4915-8626-c0b0be57cfde
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Stein, Dan J.
fa245942-40ba-471f-921b-78e9a6ad2cc1
Howells, Fleur M.
a1a51911-3a0e-4028-8a44-7cd7ffd443fa
Temmingh, Hendrik S.
dd7526e4-fd6a-4d39-a469-21cc98e8db18
Hsieh, Jennifer H.
972fe542-7c95-46c7-9fdf-83030a332c8e
van Dijen, Andrea V.
b9ece84d-1ef8-4915-8626-c0b0be57cfde
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Stein, Dan J.
fa245942-40ba-471f-921b-78e9a6ad2cc1

Howells, Fleur M., Temmingh, Hendrik S., Hsieh, Jennifer H., van Dijen, Andrea V., Baldwin, David and Stein, Dan J. (2018) Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder, and methamphetamine-induced psychotic disorder. Translational Psychiatry, 8 (1), 1-11. (doi:10.1038/s41398-018-0105-y).

Record type: Article

Abstract

Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. It is known that increased delta and decreased alpha, which are apparent in psychosis, are indicative of inappropriate arousal state, which leads to reduced ability to attend to relevant information. On this premise, we investigated delta/alpha frequency activity, as this ratio of frequency activity may serve as an effective neurophysiological biomarker. The current study investigated differences in delta/alpha frequency activity, in schizophrenia (SCZ), bipolar I disorder with psychotic features and methamphetamine-induced psychosis. One hundred and nine participants, including individuals with SCZ (n = 28), bipolar I disorder with psychotic features (n = 28), methamphetamine-induced psychotic disorder (MPD) (n = 24) and healthy controls (CON, n = 29). Diagnosis was ascertained with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition disorders and current medication was recorded. EEG was undertaken in three testing conditions: resting eyes open, resting eyes closed and during completion of a simple cognitive task (visual continuous performance task). EEG delta/alpha frequency activity was investigated across these conditions. First, delta/alpha frequency activity during resting eyes closed was higher in SCZ and MPD globally, when compared to CON, then lower for bipolar disorder (BPD) than MPD for right hemisphere. Second, delta/alpha frequency activity during resting eyes open was higher in SCZ, BPD and MPD for all electrodes, except left frontal, when compared to CON. Third, delta/alpha frequency activity during the cognitive task was higher in BPD and MPD for all electrodes, except left frontal, when compared to CON. Assessment of EEG delta/alpha frequency activity supports the delineation of underlying neurophysiological mechanisms present in psychotic disorders, which are likely related to dysfunctional thalamo-cortical connectivity. Delta/alpha frequency activity may provide a useful neurophysiological biomarker to delineate psychotic disorders.

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More information

Accepted/In Press date: 15 January 2018
e-pub ahead of print date: 12 April 2018
Published date: 18 April 2018
Keywords: delta, alpha, biomarker, psychosis, EEG, methamphetamine

Identifiers

Local EPrints ID: 419659
URI: http://eprints.soton.ac.uk/id/eprint/419659
PURE UUID: f160bc40-d8e8-4e2f-aa72-3ad3f3c1724b
ORCID for David Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

Catalogue record

Date deposited: 18 Apr 2018 16:32
Last modified: 22 Nov 2021 02:38

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Contributors

Author: Fleur M. Howells
Author: Hendrik S. Temmingh
Author: Jennifer H. Hsieh
Author: Andrea V. van Dijen
Author: David Baldwin ORCID iD
Author: Dan J. Stein

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