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Rapid aqueous late-stage radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange – towards new PET imaging probes

Rapid aqueous late-stage radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange – towards new PET imaging probes
Rapid aqueous late-stage radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange – towards new PET imaging probes
A simple and rapid method for 18F radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange is described. Using MeCN:H2O or EtOH:H2O (75:25) and 18F(aq) (up to 200 MBq) with heating (80 C, 10 mins.), gives 66±4% 18F incorporation at 268 nM concentration and 37±5% 18F incorporation at even lower (27 nM) concentration, without the need for a Lewis acid promoter. An SPE purification method has been established, giving 99% radiochemical purity (RCP) of [Ga18F19F(BnMe2-tacn)] in an EtOH/H2O mixture.
1433-7851
6658-6661
Monzittu, Francesco M.
c0124f10-1f2e-47e5-85f4-138fab36b5d4
Khan, Imtiaz
472f2db0-2192-4200-b2a7-9ac4cc798fd9
Levason, William
e7f6d7c7-643c-49f5-8b57-0ebbe1bb52cd
Luthra, Sajinder K.
fcb54474-75fa-4b01-8df7-f55c03468430
McRobbie, Graeme
b12f273f-dd78-4ff8-a423-b0b5158091c7
Reid, Gill
37d35b11-40ce-48c5-a68e-f6ce04cd4037
Monzittu, Francesco M.
c0124f10-1f2e-47e5-85f4-138fab36b5d4
Khan, Imtiaz
472f2db0-2192-4200-b2a7-9ac4cc798fd9
Levason, William
e7f6d7c7-643c-49f5-8b57-0ebbe1bb52cd
Luthra, Sajinder K.
fcb54474-75fa-4b01-8df7-f55c03468430
McRobbie, Graeme
b12f273f-dd78-4ff8-a423-b0b5158091c7
Reid, Gill
37d35b11-40ce-48c5-a68e-f6ce04cd4037

Monzittu, Francesco M., Khan, Imtiaz, Levason, William, Luthra, Sajinder K., McRobbie, Graeme and Reid, Gill (2018) Rapid aqueous late-stage radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange – towards new PET imaging probes. Angewandte Chemie - International Edition, 72 (22), 6658-6661. (doi:10.1002/anie.201802446).

Record type: Article

Abstract

A simple and rapid method for 18F radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange is described. Using MeCN:H2O or EtOH:H2O (75:25) and 18F(aq) (up to 200 MBq) with heating (80 C, 10 mins.), gives 66±4% 18F incorporation at 268 nM concentration and 37±5% 18F incorporation at even lower (27 nM) concentration, without the need for a Lewis acid promoter. An SPE purification method has been established, giving 99% radiochemical purity (RCP) of [Ga18F19F(BnMe2-tacn)] in an EtOH/H2O mixture.

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Ga radiofluorination by F-F exchange final accepted manuscript - Accepted Manuscript
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Accepted/In Press date: 10 April 2018
e-pub ahead of print date: 16 April 2018
Published date: 28 May 2018

Identifiers

Local EPrints ID: 419678
URI: http://eprints.soton.ac.uk/id/eprint/419678
ISSN: 1433-7851
PURE UUID: a5b740d6-2021-4cb2-874f-cd6d117982aa
ORCID for Francesco M. Monzittu: ORCID iD orcid.org/0000-0002-7080-3795
ORCID for William Levason: ORCID iD orcid.org/0000-0003-3540-0971
ORCID for Gill Reid: ORCID iD orcid.org/0000-0001-5349-3468

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Date deposited: 19 Apr 2018 16:30
Last modified: 18 Feb 2021 16:34

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