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Assessment of collagen fiber orientation dispersion in articular cartilage by small-angle X-ray scattering and diffusion tensor imaging: preliminary results

Assessment of collagen fiber orientation dispersion in articular cartilage by small-angle X-ray scattering and diffusion tensor imaging: preliminary results
Assessment of collagen fiber orientation dispersion in articular cartilage by small-angle X-ray scattering and diffusion tensor imaging: preliminary results

Measurements of the orientational dispersion of collagen fibers in articular cartilage were made using diffusion tensor imaging (DTI) and small-angle X-ray scattering (SAXS) on matched bovine articular cartilage samples. Thirteen pairs of samples were excised from bovine knee joints; each pair was taken from neighboring locations in the same bone. One sample from each pair was used for DTI measurements and the other for SAXS measurements. Fractional anisotropy (FA) values were calculated from the DTI data both for the individual imaging voxels and for whole regions of interest (ROI). The FA values were used as a measure of fiber dispersion and compared to the ellipticities of the fiber orientation distributions obtained from SAXS. Neither the spatially-resolved FA values nor whole-ROI FA values showed any correlation with SAXS ellipticities. We attribute the lack of DTI-SAXS correlation to two principal factors: (1) the significant difference in the imaging resolution of the two techniques; and (2) the inherent limitations of both the SAXS data analysis methodology and the diffusion tensor model in the case of multi-modal fiber orientation distributions. We discuss how these factors could be overcome in future work.

Articular cartilage, Collagen fiber dispersion, Diffusion tensor imaging (DTI), Fractional anisotropy, Orientation distribution function, Small-angle X-ray scattering (SAXS)
0730-725X
115-121
Tadimalla, Sirisha
d5025ec3-c21b-4135-a0e0-ca69e8587128
Tourell, Monique C.
cede77f9-f053-4db0-84d0-854bdf7c2aa4
Knott, Robert
4e3b8be4-cd02-4faa-8205-1180214323de
Momot, Konstantin I.
22c9f5a5-bd1b-41d1-b2e2-b33abd58b584
Tadimalla, Sirisha
d5025ec3-c21b-4135-a0e0-ca69e8587128
Tourell, Monique C.
cede77f9-f053-4db0-84d0-854bdf7c2aa4
Knott, Robert
4e3b8be4-cd02-4faa-8205-1180214323de
Momot, Konstantin I.
22c9f5a5-bd1b-41d1-b2e2-b33abd58b584

Tadimalla, Sirisha, Tourell, Monique C., Knott, Robert and Momot, Konstantin I. (2018) Assessment of collagen fiber orientation dispersion in articular cartilage by small-angle X-ray scattering and diffusion tensor imaging: preliminary results. Magnetic Resonance Imaging, 48, 115-121. (doi:10.1016/j.mri.2017.12.032).

Record type: Article

Abstract

Measurements of the orientational dispersion of collagen fibers in articular cartilage were made using diffusion tensor imaging (DTI) and small-angle X-ray scattering (SAXS) on matched bovine articular cartilage samples. Thirteen pairs of samples were excised from bovine knee joints; each pair was taken from neighboring locations in the same bone. One sample from each pair was used for DTI measurements and the other for SAXS measurements. Fractional anisotropy (FA) values were calculated from the DTI data both for the individual imaging voxels and for whole regions of interest (ROI). The FA values were used as a measure of fiber dispersion and compared to the ellipticities of the fiber orientation distributions obtained from SAXS. Neither the spatially-resolved FA values nor whole-ROI FA values showed any correlation with SAXS ellipticities. We attribute the lack of DTI-SAXS correlation to two principal factors: (1) the significant difference in the imaging resolution of the two techniques; and (2) the inherent limitations of both the SAXS data analysis methodology and the diffusion tensor model in the case of multi-modal fiber orientation distributions. We discuss how these factors could be overcome in future work.

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More information

Accepted/In Press date: 29 December 2017
e-pub ahead of print date: 3 January 2018
Published date: 1 May 2018
Keywords: Articular cartilage, Collagen fiber dispersion, Diffusion tensor imaging (DTI), Fractional anisotropy, Orientation distribution function, Small-angle X-ray scattering (SAXS)

Identifiers

Local EPrints ID: 419801
URI: https://eprints.soton.ac.uk/id/eprint/419801
ISSN: 0730-725X
PURE UUID: b33be84d-2bf1-44c2-b790-200fa10c7626

Catalogue record

Date deposited: 20 Apr 2018 16:30
Last modified: 13 Mar 2019 18:40

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