The University of Southampton
University of Southampton Institutional Repository

Altered neurophysiological processing of auditory attention in preschool children with sickle cell disease

Altered neurophysiological processing of auditory attention in preschool children with sickle cell disease
Altered neurophysiological processing of auditory attention in preschool children with sickle cell disease

Objective: Sickle cell disease (SCD) is a genetic red blood cell disorder that often leads to stroke and executive dysfunction in school-age children and adults. This study aimed to characterize the development of the neural correlates of selective attention, an early component of executive function, in preschool children with SCD.

Methods: Auditory event-related potentials (ERPs) were recorded while children attended to a story stream in one ear and ignored a second story in the other ear interchangeably. In total, 12 patients (mean age = 5.5, 7 males) and 22 typically developing children (mean age = 4.4, 10 males) were included in the final analyses.

Results: By 100 ms, more positive ERP amplitudes were observed for attended relative to unattended stimuli in typically developing children but not those with SCD, suggesting deficits in the ability to focus attention. Reduced attention effects were associated with lower performance intellectual quotient.

Conclusion: There are deficits in early attention modulation in young children with SCD.

Journal Article
0146-8693
Downes, Michelle
668e4207-edc2-4834-b0ca-24d5375ef586
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Telfer, Paul T
4f57150d-6011-4689-82ab-d32aa65f32c7
de Haan, Michelle
72c96996-93a0-4629-9c61-4efc7c6e697d
Downes, Michelle
668e4207-edc2-4834-b0ca-24d5375ef586
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Telfer, Paul T
4f57150d-6011-4689-82ab-d32aa65f32c7
de Haan, Michelle
72c96996-93a0-4629-9c61-4efc7c6e697d

Downes, Michelle, Kirkham, Fenella J., Telfer, Paul T and de Haan, Michelle (2017) Altered neurophysiological processing of auditory attention in preschool children with sickle cell disease. Journal of Pediatric Psychology. (doi:10.1093/jpepsy/jsx115).

Record type: Article

Abstract

Objective: Sickle cell disease (SCD) is a genetic red blood cell disorder that often leads to stroke and executive dysfunction in school-age children and adults. This study aimed to characterize the development of the neural correlates of selective attention, an early component of executive function, in preschool children with SCD.

Methods: Auditory event-related potentials (ERPs) were recorded while children attended to a story stream in one ear and ignored a second story in the other ear interchangeably. In total, 12 patients (mean age = 5.5, 7 males) and 22 typically developing children (mean age = 4.4, 10 males) were included in the final analyses.

Results: By 100 ms, more positive ERP amplitudes were observed for attended relative to unattended stimuli in typically developing children but not those with SCD, suggesting deficits in the ability to focus attention. Reduced attention effects were associated with lower performance intellectual quotient.

Conclusion: There are deficits in early attention modulation in young children with SCD.

Text
Downes_et_al_2017 - Version of Record
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 24 August 2017
e-pub ahead of print date: 18 September 2017
Additional Information: © The Author 2017. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Keywords: Journal Article

Identifiers

Local EPrints ID: 419807
URI: https://eprints.soton.ac.uk/id/eprint/419807
ISSN: 0146-8693
PURE UUID: 05dadc08-f168-49dd-90f0-f6abd09965a2
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 20 Apr 2018 16:30
Last modified: 10 Dec 2019 01:48

Export record

Altmetrics

Contributors

Author: Michelle Downes
Author: Fenella J. Kirkham ORCID iD
Author: Paul T Telfer
Author: Michelle de Haan

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×