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The adhesins of non-typeable Haemophilus influenzae

The adhesins of non-typeable Haemophilus influenzae
The adhesins of non-typeable Haemophilus influenzae

Introduction: Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen of the respiratory tract and the greatest contributor to invasive Haemophilus disease. Additionally, in children, NTHi is responsible for the majority of otitis media (OM) which can lead to chronic infection and hearing loss. In adults, NTHi infection in the lungs is responsible for the onset of acute exacerbations in chronic obstructive pulmonary disease (COPD). Unfortunately, there is currently no vaccine available to protect against NTHi infections. Areas covered: NTHi uses an arsenal of adhesins to colonise the respiratory epithelium. The adhesins also have secondary roles that aid in the virulence of NTHi, including mechanisms that avoid immune clearance, adjust pore size to avoid antimicrobial destruction, form micro-colonies and invoke phase variation for protein mediation. Bacterial adhesins can also be ideal antigens for subunit vaccine design due to surface exposure and immunogenic capabilities. Expert commentary: The host-pathogen interactions of the NTHi adhesins are not fully investigated. The relationship between adhesins and the extracellular matrix (ECM) play a part in the success of NTHi colonisation and virulence by immune evasion, migration and biofilm development. Further research into these immunogenic proteins would further our understanding and enable a basis for better combatting NTHi disease.

Adherence, colonisation, Haemophilus influenzae, immune evasion, immunogen, non-typeable, vaccine, virulence
1478-7210
187-196
Osman, Karen L.
9df79583-5da6-480e-ad25-189e8a4d63f2
Jefferies, Johanna M.
d3c7f86b-c08e-4c8f-9ce1-c2ac5a511746
Woelk, Christopher H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Cleary, David W.
f4079c6d-d54b-4108-b346-b0069035bec0
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Osman, Karen L.
9df79583-5da6-480e-ad25-189e8a4d63f2
Jefferies, Johanna M.
d3c7f86b-c08e-4c8f-9ce1-c2ac5a511746
Woelk, Christopher H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Cleary, David W.
f4079c6d-d54b-4108-b346-b0069035bec0
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17

Osman, Karen L., Jefferies, Johanna M., Woelk, Christopher H., Cleary, David W. and Clarke, Stuart C. (2018) The adhesins of non-typeable Haemophilus influenzae. Expert Review of Anti-Infective Therapy, 16 (3), 187-196. (doi:10.1080/14787210.2018.1438263).

Record type: Review

Abstract

Introduction: Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen of the respiratory tract and the greatest contributor to invasive Haemophilus disease. Additionally, in children, NTHi is responsible for the majority of otitis media (OM) which can lead to chronic infection and hearing loss. In adults, NTHi infection in the lungs is responsible for the onset of acute exacerbations in chronic obstructive pulmonary disease (COPD). Unfortunately, there is currently no vaccine available to protect against NTHi infections. Areas covered: NTHi uses an arsenal of adhesins to colonise the respiratory epithelium. The adhesins also have secondary roles that aid in the virulence of NTHi, including mechanisms that avoid immune clearance, adjust pore size to avoid antimicrobial destruction, form micro-colonies and invoke phase variation for protein mediation. Bacterial adhesins can also be ideal antigens for subunit vaccine design due to surface exposure and immunogenic capabilities. Expert commentary: The host-pathogen interactions of the NTHi adhesins are not fully investigated. The relationship between adhesins and the extracellular matrix (ECM) play a part in the success of NTHi colonisation and virulence by immune evasion, migration and biofilm development. Further research into these immunogenic proteins would further our understanding and enable a basis for better combatting NTHi disease.

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Accepted/In Press date: 5 February 2018
e-pub ahead of print date: 21 February 2018
Published date: 4 March 2018
Keywords: Adherence, colonisation, Haemophilus influenzae, immune evasion, immunogen, non-typeable, vaccine, virulence

Identifiers

Local EPrints ID: 419929
URI: https://eprints.soton.ac.uk/id/eprint/419929
ISSN: 1478-7210
PURE UUID: f4494471-c5a2-4e87-8365-cb2c86e5d55b
ORCID for David W. Cleary: ORCID iD orcid.org/0000-0003-4533-0700
ORCID for Stuart C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548

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Date deposited: 23 Apr 2018 16:30
Last modified: 03 Dec 2019 05:30

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