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UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion

UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion
UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion
Toll like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer. For this reason, over the last two decades, TLR and their associated signalling pathways have been targeted therapeutically to enhance innate and adaptive immunity. Several TLR ligands, both endogenous and synthetic are at various phases of clinical testing, and new ligands are continually emerging. Agonists of TLR7 are known immune response modifiers, simultaneously stimulating several cell types, resulting in immune cell activation and cytokine and chemokine release. The immune stimulating properties of the TLR7 agonist Imiquimod has also been exploited for use in the treatment of malignant superficial tumours of the skin. Here, we investigated a novel TLR7 agonist UC-1V150 and demonstrate it activates both human and mouse myeloid cells in vitro and in vivo, to deliver potent FcγR mediated engulfment of opsonised target cells.
0300-9475
Dahal, Lekh
1e993a7a-b007-4187-82ea-e28dd3920b66
Gadd, Adam
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Edwards, Alexander
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Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Beers, Stephen
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Dahal, Lekh
1e993a7a-b007-4187-82ea-e28dd3920b66
Gadd, Adam
fffcfd03-823c-40a7-9b43-2fa58716bcb3
Edwards, Alexander
97da6010-9321-48cb-b928-ad75ac6688f1
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Beers, Stephen
a02548be-3ffd-41ab-9db8-d6e8c3b499a2

Dahal, Lekh, Gadd, Adam, Edwards, Alexander, Cragg, Mark and Beers, Stephen (2018) UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion. Scandinavian Journal of Immunology. (doi:10.1111/sji.12666).

Record type: Article

Abstract

Toll like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer. For this reason, over the last two decades, TLR and their associated signalling pathways have been targeted therapeutically to enhance innate and adaptive immunity. Several TLR ligands, both endogenous and synthetic are at various phases of clinical testing, and new ligands are continually emerging. Agonists of TLR7 are known immune response modifiers, simultaneously stimulating several cell types, resulting in immune cell activation and cytokine and chemokine release. The immune stimulating properties of the TLR7 agonist Imiquimod has also been exploited for use in the treatment of malignant superficial tumours of the skin. Here, we investigated a novel TLR7 agonist UC-1V150 and demonstrate it activates both human and mouse myeloid cells in vitro and in vivo, to deliver potent FcγR mediated engulfment of opsonised target cells.

Text
SJI manuscript Lekh March 2018 - Accepted Manuscript
Restricted to Repository staff only until 18 April 2019.
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More information

Accepted/In Press date: 17 April 2018
e-pub ahead of print date: 18 April 2018

Identifiers

Local EPrints ID: 419989
URI: https://eprints.soton.ac.uk/id/eprint/419989
ISSN: 0300-9475
PURE UUID: c35da533-22b4-4eb3-8af2-99646cb8e53d
ORCID for Mark Cragg: ORCID iD orcid.org/0000-0003-2077-089X

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Date deposited: 25 Apr 2018 16:30
Last modified: 17 Jul 2019 17:22

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