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Integrin activation: Implications for axon regeneration

Integrin activation: Implications for axon regeneration
Integrin activation: Implications for axon regeneration
Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.
extracellular matrix, gene therapy, integrin activation, kindlin, regeneration, talin, tenascin
Cheah, Menghon
8aa20a25-955e-4b4f-a324-3fec1e1e8e95
Andrews, Melissa R.
ae987a2f-878e-4ae3-a7a3-a7170712096c
Cheah, Menghon
8aa20a25-955e-4b4f-a324-3fec1e1e8e95
Andrews, Melissa R.
ae987a2f-878e-4ae3-a7a3-a7170712096c

Cheah, Menghon and Andrews, Melissa R. (2018) Integrin activation: Implications for axon regeneration. Cells, 7 (3). (doi:10.3390/cells7030020).

Record type: Review

Abstract

Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.

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Accepted/In Press date: 9 March 2018
e-pub ahead of print date: 10 March 2018
Published date: 10 March 2018
Keywords: extracellular matrix, gene therapy, integrin activation, kindlin, regeneration, talin, tenascin

Identifiers

Local EPrints ID: 420003
URI: http://eprints.soton.ac.uk/id/eprint/420003
PURE UUID: 67d9ba1a-90bc-4020-bf89-5c52c23b2988
ORCID for Melissa R. Andrews: ORCID iD orcid.org/0000-0001-5960-5619

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Date deposited: 25 Apr 2018 16:30
Last modified: 22 Nov 2021 03:14

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Author: Menghon Cheah

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