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Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk

Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk
Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk

Long non-coding RNAs (lncRNAs) are a diverse class of RNA transcripts which have limited protein coding potential. They perform a variety of cellular functions in health, but have also been implicated during malignant transformation. A further theme in recent years is the critical role of the tumour microenvironment and the dynamic interactions between cancer and stromal cells in promoting invasion and disease progression. Whereas the contribution of deregulated lncRNAs within cancer cells has received considerable attention, their significance within the tumour microenvironment is less well understood. The tumour microenvironment consists of cancer-associated stromal cells and structural extracellular components which interact with one another and with the transformed epithelium via complex extracellular signalling pathways. LncRNAs are directly and indirectly involved in tumour/stroma cross-talk and help stimulate a permissive tumour microenvironment which is more conducive for invasive tumour growth. Furthermore, lncRNAs play key roles in determining the phenotype of cancer associated stromal cells and contribute to angiogenesis and immune evasion pathways, extracellular-matrix (ECM) turnover and the response to hypoxic stress. Here we explore the multifaceted roles of lncRNAs within the tumour microenvironment and their putative pathophysiological effects.

Exosomes, Extracellular signalling, Long non-coding RNA, Stroma, Tumour microenvironment
0304-3835
94-102
Del Vecchio, Filippo
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Lee, Gui Han
563bd569-ef2e-44ec-b1ca-b11be716ff40
Hawezi, Joamir
18d5b3c7-ec61-40c3-a8c0-b88e4c3f0ec7
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Pugh, Sian
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Sayan, Emre
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Thomas, Gareth
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Packham, Graham
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Primrose, John
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Pichler, Martin
e152765b-e3f2-40bb-9021-4f124f70cc89
Mirnezami, Alexander
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Calin, George
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Bullock, Marc
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Del Vecchio, Filippo
df19608c-9cd6-4f4e-aaa5-8b1c29ca56ab
Lee, Gui Han
563bd569-ef2e-44ec-b1ca-b11be716ff40
Hawezi, Joamir
18d5b3c7-ec61-40c3-a8c0-b88e4c3f0ec7
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Pugh, Sian
83010563-0865-446c-ba71-95e2a45d9562
Sayan, Emre
d7c475dd-ae7e-42c6-9dd3-1484b60ce6a1
Thomas, Gareth
2ff54aa9-a766-416b-91ee-cf1c5be74106
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Primrose, John
d85f3b28-24c6-475f-955b-ec457a3f9185
Pichler, Martin
e152765b-e3f2-40bb-9021-4f124f70cc89
Mirnezami, Alexander
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Calin, George
8abf6199-5127-412c-b29d-4c629edad2d2
Bullock, Marc
1c251c82-7dc6-4df8-9ba2-6b55a4daf947

Del Vecchio, Filippo, Lee, Gui Han, Hawezi, Joamir, Bhome, Rahul, Pugh, Sian, Sayan, Emre, Thomas, Gareth, Packham, Graham, Primrose, John, Pichler, Martin, Mirnezami, Alexander, Calin, George and Bullock, Marc (2018) Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk. Cancer Letters, 421, 94-102. (doi:10.1016/j.canlet.2018.02.022).

Record type: Review

Abstract

Long non-coding RNAs (lncRNAs) are a diverse class of RNA transcripts which have limited protein coding potential. They perform a variety of cellular functions in health, but have also been implicated during malignant transformation. A further theme in recent years is the critical role of the tumour microenvironment and the dynamic interactions between cancer and stromal cells in promoting invasion and disease progression. Whereas the contribution of deregulated lncRNAs within cancer cells has received considerable attention, their significance within the tumour microenvironment is less well understood. The tumour microenvironment consists of cancer-associated stromal cells and structural extracellular components which interact with one another and with the transformed epithelium via complex extracellular signalling pathways. LncRNAs are directly and indirectly involved in tumour/stroma cross-talk and help stimulate a permissive tumour microenvironment which is more conducive for invasive tumour growth. Furthermore, lncRNAs play key roles in determining the phenotype of cancer associated stromal cells and contribute to angiogenesis and immune evasion pathways, extracellular-matrix (ECM) turnover and the response to hypoxic stress. Here we explore the multifaceted roles of lncRNAs within the tumour microenvironment and their putative pathophysiological effects.

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lncRNA review MBv4 - Accepted Manuscript
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More information

Accepted/In Press date: 12 February 2018
e-pub ahead of print date: 17 February 2018
Published date: 1 May 2018
Keywords: Exosomes, Extracellular signalling, Long non-coding RNA, Stroma, Tumour microenvironment

Identifiers

Local EPrints ID: 420063
URI: https://eprints.soton.ac.uk/id/eprint/420063
ISSN: 0304-3835
PURE UUID: 90bcc8f6-0382-4718-8bf9-a7f9464305f3
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691
ORCID for John Primrose: ORCID iD orcid.org/0000-0002-2069-7605

Catalogue record

Date deposited: 25 Apr 2018 16:31
Last modified: 14 Mar 2019 05:12

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