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Targeting head and neck cancer by vaccination

Targeting head and neck cancer by vaccination
Targeting head and neck cancer by vaccination
Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC. Novel therapeutic approaches for HNC will focus not only on effective vaccine platforms but will also target the stroma-rich immunosuppressive microenvironment found in those tumours.
1664-3224
1-12
Wang, Chuan
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Dickie, James
d278ec65-5598-40dc-a614-a47933790297
Sutavani, Ruhcha
d47fe50a-5f9f-4fbe-9d9c-cea576762d46
Pointer, Catherine
d6f6a5dd-78a7-4a4d-a2f8-600096545126
Thomas, Gareth
2ff54aa9-a766-416b-91ee-cf1c5be74106
Savelyeva, Natalia
804c3e15-d260-4717-9b7c-15c16ba87fc7
Wang, Chuan
f293763a-7eba-4d8e-a496-3b5e25a1a171
Dickie, James
d278ec65-5598-40dc-a614-a47933790297
Sutavani, Ruhcha
d47fe50a-5f9f-4fbe-9d9c-cea576762d46
Pointer, Catherine
d6f6a5dd-78a7-4a4d-a2f8-600096545126
Thomas, Gareth
2ff54aa9-a766-416b-91ee-cf1c5be74106
Savelyeva, Natalia
804c3e15-d260-4717-9b7c-15c16ba87fc7

Wang, Chuan, Dickie, James, Sutavani, Ruhcha, Pointer, Catherine, Thomas, Gareth and Savelyeva, Natalia (2018) Targeting head and neck cancer by vaccination. Frontiers in Immunology, 1-12. (doi:10.3389/fimmu.2018.00830).

Record type: Article

Abstract

Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC. Novel therapeutic approaches for HNC will focus not only on effective vaccine platforms but will also target the stroma-rich immunosuppressive microenvironment found in those tumours.

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fimmu-09-00603
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More information

Accepted/In Press date: 5 April 2018
e-pub ahead of print date: 23 April 2018

Identifiers

Local EPrints ID: 420086
URI: https://eprints.soton.ac.uk/id/eprint/420086
ISSN: 1664-3224
PURE UUID: b0d9c66c-9d52-43b3-b744-bba091881810

Catalogue record

Date deposited: 26 Apr 2018 16:30
Last modified: 13 Mar 2019 18:35

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Contributors

Author: Chuan Wang
Author: James Dickie
Author: Ruhcha Sutavani
Author: Catherine Pointer
Author: Gareth Thomas

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