The University of Southampton
University of Southampton Institutional Repository

Immunomodulatory role of branched-chain amino acids

Immunomodulatory role of branched-chain amino acids
Immunomodulatory role of branched-chain amino acids
Branched-chain amino acids (BCAAs) have been associated with immunomodulation since the mid-1970s and 1980s and have been used in the nutritional therapy of critically ill patients. Evidence shows that BCAAs can directly contribute to immune cell function, aiding recovery of an impaired immune system, as well as improving the nutritional status in cancer and liver diseases. Branched-chain amino acids may also play a role in treatment of patients with sepsis or trauma, contributing to improved clinical outcomes and survival. Branched-chain amino acids, especially leucine, are activators of the mammalian target of rapamycin (mTOR), which, in turn, interacts with several signaling pathways involved in biological mechanisms of insulin action, protein synthesis, mitochondrial biogenesis, inflammation, and lipid metabolism. Although many in vitro and human and animal model studies have provided evidence for the biological activity of BCAAs, findings have been conflicting, and the mechanisms of action of these amino acids are still poorly understood. This review addresses several aspects related to BCAAs, including their transport, oxidation, and mechanisms of action, as well as their role in nutritional therapy and immunomodulation.
0029-6643
840-856
Bonvini, Andrea
8171a39c-353e-4f7f-9e99-3b992a6f87c9
Coqueiro, Audrey Y.
1fb18031-c3c4-460e-9e55-a944e21f4f37
Tirapegui, Julio
6c8373f2-ef7b-4976-965c-30449a5dbed3
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Rogero, Marcelo M.
e77428d6-aaf4-4aec-8d72-b4b38434bd82
Bonvini, Andrea
8171a39c-353e-4f7f-9e99-3b992a6f87c9
Coqueiro, Audrey Y.
1fb18031-c3c4-460e-9e55-a944e21f4f37
Tirapegui, Julio
6c8373f2-ef7b-4976-965c-30449a5dbed3
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Rogero, Marcelo M.
e77428d6-aaf4-4aec-8d72-b4b38434bd82

Bonvini, Andrea, Coqueiro, Audrey Y., Tirapegui, Julio, Calder, Philip and Rogero, Marcelo M. (2018) Immunomodulatory role of branched-chain amino acids. Nutrition Reviews, 76 (11), 840-856. (doi:10.1093/nutrit/nuy037).

Record type: Article

Abstract

Branched-chain amino acids (BCAAs) have been associated with immunomodulation since the mid-1970s and 1980s and have been used in the nutritional therapy of critically ill patients. Evidence shows that BCAAs can directly contribute to immune cell function, aiding recovery of an impaired immune system, as well as improving the nutritional status in cancer and liver diseases. Branched-chain amino acids may also play a role in treatment of patients with sepsis or trauma, contributing to improved clinical outcomes and survival. Branched-chain amino acids, especially leucine, are activators of the mammalian target of rapamycin (mTOR), which, in turn, interacts with several signaling pathways involved in biological mechanisms of insulin action, protein synthesis, mitochondrial biogenesis, inflammation, and lipid metabolism. Although many in vitro and human and animal model studies have provided evidence for the biological activity of BCAAs, findings have been conflicting, and the mechanisms of action of these amino acids are still poorly understood. This review addresses several aspects related to BCAAs, including their transport, oxidation, and mechanisms of action, as well as their role in nutritional therapy and immunomodulation.

Text
Bonvini Main Document - Accepted Manuscript
Download (321kB)
Text
Bonvini Figure 1 - Accepted Manuscript
Download (67kB)
Text
Bonvini Figure 2 - Accepted Manuscript
Download (48kB)
Text
Bonvini_Figure 3 - Accepted Manuscript
Restricted to Repository staff only
Request a copy
Text
Bonvini_Figure 4 - Accepted Manuscript
Restricted to Repository staff only
Request a copy

Show all 5 downloads.

More information

Accepted/In Press date: 25 April 2018
e-pub ahead of print date: 9 October 2018
Published date: 1 November 2018

Identifiers

Local EPrints ID: 420265
URI: http://eprints.soton.ac.uk/id/eprint/420265
ISSN: 0029-6643
PURE UUID: 697a77d7-e1c4-42c9-96c0-51a606997052

Catalogue record

Date deposited: 03 May 2018 16:30
Last modified: 17 Dec 2019 05:27

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×