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Imaging care requirements: use of functional neuroimaging to predict dementia caregiver burden

Imaging care requirements: use of functional neuroimaging to predict dementia caregiver burden
Imaging care requirements: use of functional neuroimaging to predict dementia caregiver burden

Background: dementia caregivers frequently report high stress, with increased burden associated with worse outcomes for both patients and caregivers. Although many studies relate clinical phenotypes to burden, the relationship between imaging pathology and burden, irrespective of diagnosis, is unknown. This study investigated the relationship between caregiver burden and patient regional cerebral blood flow in dementia.

Methods: seventy-seven patients with cognitive impairment undergoing brain perfusion single-photon emission computed tomography imaging in normal clinical care and their caregivers were recruited. Caregiver burden was ranked from “little” to “severe” using the Zarit Burden Interview and perfusion values extracted from the patient images for predefined regions of interest. The associations between burden score and regional function on imaging were tested.

Results: Burden score was significantly higher for caregivers of patients with abnormal perfusion compared to those with normal perfusion in the left and right frontal, right parietal, and right temporal lobes. No difference in burden was found in the left parietal or temporal groups. Correlations showed that a higher caregiver burden was associated with lower patient perfusion scores in the same regions.

Conclusion: caregiver burden is strongly related to the extent of frontal or right-predominant parietal or temporal lobe dysfunction. Regional abnormality on perfusion imaging can be used to facilitate identification of individuals who are likely to create a high burden on caregivers.

Caregiver burden, Dementia, Neuroimaging, Single-photon emission computed tomography, Zarit Burden Interview
180-189
Prosser, Angus M.J.
de1efee5-67f5-478e-8cfa-12a8e78a68e5
Spreadbury, John H.
164cd819-25dc-49c0-8630-1518a80fc3e6
Tossici-Bolt, Livia
a9bd79ee-18c7-40c0-a1a8-2d826e4be759
Kipps, Christopher M.
e43be016-2dc2-45e6-9a02-ab2a0e0208d5
Prosser, Angus M.J.
de1efee5-67f5-478e-8cfa-12a8e78a68e5
Spreadbury, John H.
164cd819-25dc-49c0-8630-1518a80fc3e6
Tossici-Bolt, Livia
a9bd79ee-18c7-40c0-a1a8-2d826e4be759
Kipps, Christopher M.
e43be016-2dc2-45e6-9a02-ab2a0e0208d5

Prosser, Angus M.J., Spreadbury, John H., Tossici-Bolt, Livia and Kipps, Christopher M. (2018) Imaging care requirements: use of functional neuroimaging to predict dementia caregiver burden. Dementia and Geriatric Cognitive Disorders Extra, 8 (1), 180-189. (doi:10.1159/000486479).

Record type: Article

Abstract

Background: dementia caregivers frequently report high stress, with increased burden associated with worse outcomes for both patients and caregivers. Although many studies relate clinical phenotypes to burden, the relationship between imaging pathology and burden, irrespective of diagnosis, is unknown. This study investigated the relationship between caregiver burden and patient regional cerebral blood flow in dementia.

Methods: seventy-seven patients with cognitive impairment undergoing brain perfusion single-photon emission computed tomography imaging in normal clinical care and their caregivers were recruited. Caregiver burden was ranked from “little” to “severe” using the Zarit Burden Interview and perfusion values extracted from the patient images for predefined regions of interest. The associations between burden score and regional function on imaging were tested.

Results: Burden score was significantly higher for caregivers of patients with abnormal perfusion compared to those with normal perfusion in the left and right frontal, right parietal, and right temporal lobes. No difference in burden was found in the left parietal or temporal groups. Correlations showed that a higher caregiver burden was associated with lower patient perfusion scores in the same regions.

Conclusion: caregiver burden is strongly related to the extent of frontal or right-predominant parietal or temporal lobe dysfunction. Regional abnormality on perfusion imaging can be used to facilitate identification of individuals who are likely to create a high burden on caregivers.

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000486479 - Version of Record
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Accepted/In Press date: 22 December 2017
e-pub ahead of print date: 26 April 2018
Keywords: Caregiver burden, Dementia, Neuroimaging, Single-photon emission computed tomography, Zarit Burden Interview

Identifiers

Local EPrints ID: 420424
URI: http://eprints.soton.ac.uk/id/eprint/420424
PURE UUID: f427f3f3-0df0-49ba-87dd-67e0705ab54b
ORCID for Angus M.J. Prosser: ORCID iD orcid.org/0000-0003-2705-1222

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Date deposited: 08 May 2018 16:30
Last modified: 28 Feb 2024 03:06

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Contributors

Author: John H. Spreadbury
Author: Livia Tossici-Bolt
Author: Christopher M. Kipps

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