Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
Monodeuterated methyl groups may support a long-lived nuclear spin state, with a relaxation time exceeding the conventional spin-lattice relaxation time T1. Dissolution-DNP (dynamic nuclear polarization) may be used to hyperpolarize such a long-lived spin state. This is demonstrated for the CH2D groups of a piperidine derivative. The polarized sample is manipulated in the ambient magnetic field of the laboratory, without destruction of the hyperpolarized singlet order. Strongly enhanced CH2D signals are observed more than one minute after dissolution, even in the presence of paramagnetic radicals, by which time the NMR signal from the hyperpolarized proton magnetization has completely disappeared.
9755-9759
Elliott, Stuart J.
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Meier, Benno
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Vuichoud, Basile
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Stevanato, Gabriele
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Brown, Lynda J.
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Alonso-Valdesueiro, Javier
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Emsley, Lyndon
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Jannin, Sami
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Levitt, Malcolm H.
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2018
Elliott, Stuart J.
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Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1
Vuichoud, Basile
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Stevanato, Gabriele
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Brown, Lynda J.
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Alonso-Valdesueiro, Javier
ee87ede4-2a13-4e6e-af22-bda1d4c83517
Emsley, Lyndon
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Jannin, Sami
dc06e44e-55ab-44b8-a825-b210b6853957
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Elliott, Stuart J., Meier, Benno, Vuichoud, Basile, Stevanato, Gabriele, Brown, Lynda J., Alonso-Valdesueiro, Javier, Emsley, Lyndon, Jannin, Sami and Levitt, Malcolm H.
(2018)
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups.
Physical Chemistry Chemical Physics, 20 (15), .
(doi:10.1039/c8cp00253c).
Abstract
Monodeuterated methyl groups may support a long-lived nuclear spin state, with a relaxation time exceeding the conventional spin-lattice relaxation time T1. Dissolution-DNP (dynamic nuclear polarization) may be used to hyperpolarize such a long-lived spin state. This is demonstrated for the CH2D groups of a piperidine derivative. The polarized sample is manipulated in the ambient magnetic field of the laboratory, without destruction of the hyperpolarized singlet order. Strongly enhanced CH2D signals are observed more than one minute after dissolution, even in the presence of paramagnetic radicals, by which time the NMR signal from the hyperpolarized proton magnetization has completely disappeared.
Text
c8cp00253c
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Accepted/In Press date: 15 February 2018
e-pub ahead of print date: 29 March 2018
Published date: 2018
Identifiers
Local EPrints ID: 420535
URI: http://eprints.soton.ac.uk/id/eprint/420535
ISSN: 1463-9076
PURE UUID: 3d644523-d416-468d-a03a-0278b4e2c280
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Date deposited: 10 May 2018 16:30
Last modified: 18 Mar 2024 02:53
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Author:
Stuart J. Elliott
Author:
Benno Meier
Author:
Basile Vuichoud
Author:
Gabriele Stevanato
Author:
Javier Alonso-Valdesueiro
Author:
Lyndon Emsley
Author:
Sami Jannin
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