The University of Southampton
University of Southampton Institutional Repository

Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups

Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups

Monodeuterated methyl groups may support a long-lived nuclear spin state, with a relaxation time exceeding the conventional spin-lattice relaxation time T1. Dissolution-DNP (dynamic nuclear polarization) may be used to hyperpolarize such a long-lived spin state. This is demonstrated for the CH2D groups of a piperidine derivative. The polarized sample is manipulated in the ambient magnetic field of the laboratory, without destruction of the hyperpolarized singlet order. Strongly enhanced CH2D signals are observed more than one minute after dissolution, even in the presence of paramagnetic radicals, by which time the NMR signal from the hyperpolarized proton magnetization has completely disappeared.

1463-9076
9755-9759
Elliott, Stuart J.
6cc724de-f75f-4c0f-a00a-e712b4e73b12
Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1
Vuichoud, Basile
a5566e87-f68a-4992-a37c-8d48b93913b6
Stevanato, Gabriele
4e8bed5e-b597-4dea-9a8b-5bf886bf8a18
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Alonso-Valdesueiro, Javier
ee87ede4-2a13-4e6e-af22-bda1d4c83517
Emsley, Lyndon
3234816a-24e9-44a0-b134-70c09de78257
Jannin, Sami
dc06e44e-55ab-44b8-a825-b210b6853957
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Elliott, Stuart J.
6cc724de-f75f-4c0f-a00a-e712b4e73b12
Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1
Vuichoud, Basile
a5566e87-f68a-4992-a37c-8d48b93913b6
Stevanato, Gabriele
4e8bed5e-b597-4dea-9a8b-5bf886bf8a18
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Alonso-Valdesueiro, Javier
ee87ede4-2a13-4e6e-af22-bda1d4c83517
Emsley, Lyndon
3234816a-24e9-44a0-b134-70c09de78257
Jannin, Sami
dc06e44e-55ab-44b8-a825-b210b6853957
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3

Elliott, Stuart J., Meier, Benno, Vuichoud, Basile, Stevanato, Gabriele, Brown, Lynda J., Alonso-Valdesueiro, Javier, Emsley, Lyndon, Jannin, Sami and Levitt, Malcolm H. (2018) Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups. Physical Chemistry Chemical Physics, 20 (15), 9755-9759. (doi:10.1039/c8cp00253c).

Record type: Article

Abstract

Monodeuterated methyl groups may support a long-lived nuclear spin state, with a relaxation time exceeding the conventional spin-lattice relaxation time T1. Dissolution-DNP (dynamic nuclear polarization) may be used to hyperpolarize such a long-lived spin state. This is demonstrated for the CH2D groups of a piperidine derivative. The polarized sample is manipulated in the ambient magnetic field of the laboratory, without destruction of the hyperpolarized singlet order. Strongly enhanced CH2D signals are observed more than one minute after dissolution, even in the presence of paramagnetic radicals, by which time the NMR signal from the hyperpolarized proton magnetization has completely disappeared.

Text
c8cp00253c - Version of Record
Available under License Creative Commons Attribution.
Download (2MB)

More information

Accepted/In Press date: 15 February 2018
e-pub ahead of print date: 29 March 2018
Published date: 2018

Identifiers

Local EPrints ID: 420535
URI: https://eprints.soton.ac.uk/id/eprint/420535
ISSN: 1463-9076
PURE UUID: 3d644523-d416-468d-a03a-0278b4e2c280
ORCID for Benno Meier: ORCID iD orcid.org/0000-0003-2258-1507
ORCID for Lynda J. Brown: ORCID iD orcid.org/0000-0002-5678-0814
ORCID for Malcolm H. Levitt: ORCID iD orcid.org/0000-0001-9878-1180

Catalogue record

Date deposited: 10 May 2018 16:30
Last modified: 15 Aug 2019 00:51

Export record

Altmetrics

Contributors

Author: Stuart J. Elliott
Author: Benno Meier ORCID iD
Author: Basile Vuichoud
Author: Gabriele Stevanato
Author: Lynda J. Brown ORCID iD
Author: Javier Alonso-Valdesueiro
Author: Lyndon Emsley
Author: Sami Jannin

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×