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The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy

The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy
The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy

Aβ, amyloid beta, CAA, cerebral amyloid angiopathy, CT, computed tomographic scanning, IPAD, intramural periarterial drainage, ISF, interstitial fluid, MRI, magnetic resonance imaging, PVS, perivascular spaces, WMH, white matter hyperintensities.Cerebral white matter hyperintensities (WMH) observed on magnetic resonance imaging (MRI), or low attenuation on computed tomographic scanning (CT), are the most frequent brain imaging finding in patients with small vessel disease or dementia. It has been assumed that WMH are due to arteriosclerosis or blood-brain barrier breakdown, though recently it was demonstrated that WMH have distinct molecular signatures in Alzheimer's disease (AD) where markers of Wallerian degeneration are present, compared to normal ageing [1]. This article is protected by copyright. All rights reserved.

Journal Article
0305-1846
305-308
MacGregor Sharp, Matthew
ec57c53a-a10a-4b8a-94fe-03eca85ab7c3
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
Brandner, Sebastian
f64b2397-fa45-4378-bf5a-1c6bbb14f18e
Holton, Janice
87377c8c-bbfd-4e16-bc36-801554c0cdc4
Verma, Ajay
5a207350-0de9-487a-be28-f9eb2f558140
Werring, David J.
0caabc8a-8597-4f08-9189-e8a6e6a213a6
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
MacGregor Sharp, Matthew
ec57c53a-a10a-4b8a-94fe-03eca85ab7c3
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
Brandner, Sebastian
f64b2397-fa45-4378-bf5a-1c6bbb14f18e
Holton, Janice
87377c8c-bbfd-4e16-bc36-801554c0cdc4
Verma, Ajay
5a207350-0de9-487a-be28-f9eb2f558140
Werring, David J.
0caabc8a-8597-4f08-9189-e8a6e6a213a6
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa

MacGregor Sharp, Matthew, Bulters, Diederik, Brandner, Sebastian, Holton, Janice, Verma, Ajay, Werring, David J. and Carare, Roxana O. (2019) The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy. Neuropathology and Applied Neurobiology, 45 (3), 305-308. (doi:10.1111/nan.12480).

Record type: Article

Abstract

Aβ, amyloid beta, CAA, cerebral amyloid angiopathy, CT, computed tomographic scanning, IPAD, intramural periarterial drainage, ISF, interstitial fluid, MRI, magnetic resonance imaging, PVS, perivascular spaces, WMH, white matter hyperintensities.Cerebral white matter hyperintensities (WMH) observed on magnetic resonance imaging (MRI), or low attenuation on computed tomographic scanning (CT), are the most frequent brain imaging finding in patients with small vessel disease or dementia. It has been assumed that WMH are due to arteriosclerosis or blood-brain barrier breakdown, though recently it was demonstrated that WMH have distinct molecular signatures in Alzheimer's disease (AD) where markers of Wallerian degeneration are present, compared to normal ageing [1]. This article is protected by copyright. All rights reserved.

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More information

Accepted/In Press date: 22 February 2018
e-pub ahead of print date: 27 February 2018
Published date: April 2019
Additional Information: This article is protected by copyright. All rights reserved.
Keywords: Journal Article

Identifiers

Local EPrints ID: 420564
URI: https://eprints.soton.ac.uk/id/eprint/420564
ISSN: 0305-1846
PURE UUID: d06454fc-dff4-42b2-8a61-54ae4b1fc894
ORCID for Matthew MacGregor Sharp: ORCID iD orcid.org/0000-0002-6623-5078

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Date deposited: 10 May 2018 16:30
Last modified: 03 Dec 2019 05:26

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