The University of Southampton
University of Southampton Institutional Repository

Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia

Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia
Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia

OBJECTIVE: To identify factors associated with asthma associated with increased sickle cell anemia (SCA).

STUDY DESIGN: Children with SCA (N = 187; mean age 9.6 years, 48% male) were classified as having "asthma" based on parent report of physician diagnosis plus prescription of asthma medication (n = 53) or "no asthma" based on the absence of these features (n = 134). Pain and acute chest syndrome (ACS) events were collected prospectively.

RESULTS: Multiple variable logistic regression model identified 3 factors associated with asthma: parent with asthma (P = .006), wheezing causing shortness of breath (P = .001), and wheezing after exercise (P < .001). When ≥2 features were present, model sensitivity was 100%. When none of the features were present, model sensitivity was 0%. When only 1 feature was present, model sensitivity was also 0%, and presence of ≥2 of positive allergy skin tests, airway obstruction on spirometry, and bronchodilator responsiveness did not improve clinical utility. ACS incident rates were significantly higher in individuals with asthma than in those without asthma (incident rate ratio 2.21, CI 1.31-3.76), but pain rates were not (incident rate ratio 1.28, CI 0.78-2.10).

CONCLUSIONS: For children with SCA, having a parent with asthma and specific wheezing symptoms are the best features to distinguish those with and without parent report of a physician diagnosis of asthma and to identify those at higher risk for ACS events. The value of treatment for asthma in the prevention of SCA morbidity needs to be studied.

Acute Chest Syndrome, Anemia, Sickle Cell, Asthma, Child, Family Health, Female, Follow-Up Studies, Humans, Male, Parents, Prospective Studies, Respiratory Sounds, Journal Article, Research Support, N.I.H., Extramural
0022-3476
821-826.e1
Strunk, Robert C.
014a33a8-1e21-4ee9-8b32-2cfb453f033d
Cohen, Robyn T.
68312680-d8a7-4a08-9e1e-2eff5e924bfe
Cooper, Benjamin P.
bbcc13ef-f529-4a2f-8e0e-f8f2cde2f240
Rodeghier, Mark
fa844b56-b6c4-4dd5-affd-f56b0b23e24e
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Warner, John O.
50630e99-8486-4859-ade3-cd2c79c5a153
Stocks, Janet
b2cd1933-aa00-483a-b996-74cdd2bfd09e
Kirkby, Jane
f7468439-d939-4b22-9728-af7671014910
Roberts, Irene
6e025a6a-755f-4340-9a45-a99b0fde116b
Rosen, Carol L.
3a8d9aa4-397d-47f6-8791-3df3e42eb1a5
Craven, Daniel I.
724db4d4-4ad2-40f2-8dd2-cc66c2ae7854
DeBaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe
Sleep Asthma Cohort Investigative Team
Strunk, Robert C.
014a33a8-1e21-4ee9-8b32-2cfb453f033d
Cohen, Robyn T.
68312680-d8a7-4a08-9e1e-2eff5e924bfe
Cooper, Benjamin P.
bbcc13ef-f529-4a2f-8e0e-f8f2cde2f240
Rodeghier, Mark
fa844b56-b6c4-4dd5-affd-f56b0b23e24e
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Warner, John O.
50630e99-8486-4859-ade3-cd2c79c5a153
Stocks, Janet
b2cd1933-aa00-483a-b996-74cdd2bfd09e
Kirkby, Jane
f7468439-d939-4b22-9728-af7671014910
Roberts, Irene
6e025a6a-755f-4340-9a45-a99b0fde116b
Rosen, Carol L.
3a8d9aa4-397d-47f6-8791-3df3e42eb1a5
Craven, Daniel I.
724db4d4-4ad2-40f2-8dd2-cc66c2ae7854
DeBaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe

Strunk, Robert C., Cohen, Robyn T., Cooper, Benjamin P., Rodeghier, Mark, Kirkham, Fenella J., Warner, John O., Stocks, Janet, Kirkby, Jane, Roberts, Irene, Rosen, Carol L., Craven, Daniel I. and DeBaun, Michael R. , Sleep Asthma Cohort Investigative Team (2014) Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia. Journal of Pediatrics, 164 (4), 821-826.e1. (doi:10.1016/j.jpeds.2013.11.034).

Record type: Article

Abstract

OBJECTIVE: To identify factors associated with asthma associated with increased sickle cell anemia (SCA).

STUDY DESIGN: Children with SCA (N = 187; mean age 9.6 years, 48% male) were classified as having "asthma" based on parent report of physician diagnosis plus prescription of asthma medication (n = 53) or "no asthma" based on the absence of these features (n = 134). Pain and acute chest syndrome (ACS) events were collected prospectively.

RESULTS: Multiple variable logistic regression model identified 3 factors associated with asthma: parent with asthma (P = .006), wheezing causing shortness of breath (P = .001), and wheezing after exercise (P < .001). When ≥2 features were present, model sensitivity was 100%. When none of the features were present, model sensitivity was 0%. When only 1 feature was present, model sensitivity was also 0%, and presence of ≥2 of positive allergy skin tests, airway obstruction on spirometry, and bronchodilator responsiveness did not improve clinical utility. ACS incident rates were significantly higher in individuals with asthma than in those without asthma (incident rate ratio 2.21, CI 1.31-3.76), but pain rates were not (incident rate ratio 1.28, CI 0.78-2.10).

CONCLUSIONS: For children with SCA, having a parent with asthma and specific wheezing symptoms are the best features to distinguish those with and without parent report of a physician diagnosis of asthma and to identify those at higher risk for ACS events. The value of treatment for asthma in the prevention of SCA morbidity needs to be studied.

Full text not available from this repository.

More information

e-pub ahead of print date: 31 December 2013
Published date: April 2014
Additional Information: Copyright © 2014 Mosby, Inc. All rights reserved.
Keywords: Acute Chest Syndrome, Anemia, Sickle Cell, Asthma, Child, Family Health, Female, Follow-Up Studies, Humans, Male, Parents, Prospective Studies, Respiratory Sounds, Journal Article, Research Support, N.I.H., Extramural

Identifiers

Local EPrints ID: 420593
URI: https://eprints.soton.ac.uk/id/eprint/420593
ISSN: 0022-3476
PURE UUID: d982588c-4a5d-42dc-b56a-0e2f723bed0e
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 10 May 2018 16:30
Last modified: 17 Sep 2019 01:01

Export record

Altmetrics

Contributors

Author: Robert C. Strunk
Author: Robyn T. Cohen
Author: Benjamin P. Cooper
Author: Mark Rodeghier
Author: Fenella J. Kirkham ORCID iD
Author: John O. Warner
Author: Janet Stocks
Author: Jane Kirkby
Author: Irene Roberts
Author: Carol L. Rosen
Author: Daniel I. Craven
Author: Michael R. DeBaun

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×