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Arterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal 'reference range' values and their use in clinical studies

Arterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal 'reference range' values and their use in clinical studies
Arterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal 'reference range' values and their use in clinical studies

The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T₁) and equilibrium longitudinal magnetization (M₀). We present mean and reference ranges for normal values of T₁, M₀, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T₁ relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M₀ anteriorly, but posteriorly, males but not females showed a significant decline in M₀ with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated.

Adolescent, Adult, Brain, Cerebrovascular Circulation, Child, Female, Hemodynamics, Humans, Magnetic Resonance Imaging, Male, Spin Labels, Young Adult, Journal Article, Research Support, Non-U.S. Gov't
0271-678X
776-784
Hales, Patrick W.
4f79496e-1c36-4bba-bb4d-d46974307f4f
Kawadler, Jamie M.
7d035760-69ea-4b6c-8a7a-771b73453db8
Aylett, Sarah E.
a944fa5a-e1f1-45ca-9879-2056d2946438
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Clark, Christopher A.
b7466af5-d869-466d-8733-6a450950ae3c
Hales, Patrick W.
4f79496e-1c36-4bba-bb4d-d46974307f4f
Kawadler, Jamie M.
7d035760-69ea-4b6c-8a7a-771b73453db8
Aylett, Sarah E.
a944fa5a-e1f1-45ca-9879-2056d2946438
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Clark, Christopher A.
b7466af5-d869-466d-8733-6a450950ae3c

Hales, Patrick W., Kawadler, Jamie M., Aylett, Sarah E., Kirkham, Fenella J. and Clark, Christopher A. (2014) Arterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal 'reference range' values and their use in clinical studies. Journal of Cerebral Blood Flow & Metabolism, 34 (5), 776-784. (doi:10.1038/jcbfm.2014.17).

Record type: Article

Abstract

The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T₁) and equilibrium longitudinal magnetization (M₀). We present mean and reference ranges for normal values of T₁, M₀, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T₁ relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M₀ anteriorly, but posteriorly, males but not females showed a significant decline in M₀ with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated.

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More information

e-pub ahead of print date: 5 February 2014
Published date: May 2014
Keywords: Adolescent, Adult, Brain, Cerebrovascular Circulation, Child, Female, Hemodynamics, Humans, Magnetic Resonance Imaging, Male, Spin Labels, Young Adult, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 420594
URI: https://eprints.soton.ac.uk/id/eprint/420594
ISSN: 0271-678X
PURE UUID: c069c248-a73c-4ca3-aea6-c1b84111e244
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 10 May 2018 16:30
Last modified: 19 Nov 2019 01:51

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