Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non-Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56-0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa.
Journal Article
273-276
Makani, Julie
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Mgaya, Josephine
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Balandya, Emmanuel
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Msami, Khadija
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Soka, Deogratias
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Cox, Sharon E.
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Komba, Albert N
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Rwezaula, Stella
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Meda, Elineema
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Muturi, David
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Kitundu, Jesse
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Fegan, Gregory
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Kirkham, Fenella J.
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Newton, Charles R
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Snow, Robert W
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Lowe, Brett
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October 2015
Makani, Julie
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Mgaya, Josephine
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Balandya, Emmanuel
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Msami, Khadija
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Soka, Deogratias
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Cox, Sharon E.
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Komba, Albert N
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Rwezaula, Stella
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Meda, Elineema
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Muturi, David
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Kitundu, Jesse
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Fegan, Gregory
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Kirkham, Fenella J.
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Newton, Charles R
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Snow, Robert W
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Lowe, Brett
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Makani, Julie, Mgaya, Josephine, Balandya, Emmanuel, Msami, Khadija, Soka, Deogratias, Cox, Sharon E., Komba, Albert N, Rwezaula, Stella, Meda, Elineema, Muturi, David, Kitundu, Jesse, Fegan, Gregory, Kirkham, Fenella J., Newton, Charles R, Snow, Robert W and Lowe, Brett
(2015)
Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania.
British Journal of Haematology, 273-276, .
(doi:10.1111/bjh.13553).
Abstract
Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non-Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56-0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa.
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Makani_et_al-2015-British_Journal_of_Haematology
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Accepted/In Press date: 17 May 2015
e-pub ahead of print date: 17 June 2015
Published date: October 2015
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Journal Article
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Local EPrints ID: 420603
URI: http://eprints.soton.ac.uk/id/eprint/420603
ISSN: 0007-1048
PURE UUID: cce508b3-ae2f-49ae-9f7d-51a38fdd4a1c
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Date deposited: 10 May 2018 16:31
Last modified: 16 Mar 2024 03:22
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Contributors
Author:
Julie Makani
Author:
Josephine Mgaya
Author:
Emmanuel Balandya
Author:
Khadija Msami
Author:
Deogratias Soka
Author:
Sharon E. Cox
Author:
Albert N Komba
Author:
Stella Rwezaula
Author:
Elineema Meda
Author:
David Muturi
Author:
Jesse Kitundu
Author:
Gregory Fegan
Author:
Charles R Newton
Author:
Robert W Snow
Author:
Brett Lowe
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