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Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania

Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania

Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non-Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56-0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa.

Journal Article
0007-1048
273-276
Makani, Julie
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Mgaya, Josephine
740b5114-40dc-4020-bbe0-c54475f34328
Balandya, Emmanuel
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Msami, Khadija
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Soka, Deogratias
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Cox, Sharon E.
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Komba, Albert N
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Rwezaula, Stella
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Meda, Elineema
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Muturi, David
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Kitundu, Jesse
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Fegan, Gregory
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Kirkham, Fenella J.
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Newton, Charles R
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Snow, Robert W
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Lowe, Brett
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Makani, Julie
76a145a7-02fc-43ea-a1df-3a52d2004e48
Mgaya, Josephine
740b5114-40dc-4020-bbe0-c54475f34328
Balandya, Emmanuel
90297c1c-b526-4fcf-b028-48ce9fbaf176
Msami, Khadija
06824b22-8f40-4f5b-94a5-998515bc73a0
Soka, Deogratias
493329a2-35e6-4fce-9402-bcfe516ab775
Cox, Sharon E.
c9298a16-f75d-4174-892e-808395020fd6
Komba, Albert N
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Rwezaula, Stella
e53c9209-221b-4a45-97c4-17ebacf323dc
Meda, Elineema
ee3ff767-895e-4d3f-804f-3a749700a350
Muturi, David
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Kitundu, Jesse
bf011bd1-51ac-45ad-99c7-0a3adada74b8
Fegan, Gregory
665c804f-5687-40f3-b40c-ccd88540f7aa
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Newton, Charles R
ea661613-9a2d-4e14-8d04-2d1c0804a321
Snow, Robert W
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Lowe, Brett
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Makani, Julie, Mgaya, Josephine, Balandya, Emmanuel, Msami, Khadija, Soka, Deogratias, Cox, Sharon E., Komba, Albert N, Rwezaula, Stella, Meda, Elineema, Muturi, David, Kitundu, Jesse, Fegan, Gregory, Kirkham, Fenella J., Newton, Charles R, Snow, Robert W and Lowe, Brett (2015) Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania. British Journal of Haematology, 273-276, 273-276. (doi:10.1111/bjh.13553).

Record type: Article

Abstract

Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non-Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56-0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa.

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Accepted/In Press date: 17 May 2015
e-pub ahead of print date: 17 June 2015
Published date: October 2015
Additional Information: © 2015 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.
Keywords: Journal Article

Identifiers

Local EPrints ID: 420603
URI: https://eprints.soton.ac.uk/id/eprint/420603
ISSN: 0007-1048
PURE UUID: cce508b3-ae2f-49ae-9f7d-51a38fdd4a1c
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 10 May 2018 16:31
Last modified: 13 Jun 2019 00:37

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Contributors

Author: Julie Makani
Author: Josephine Mgaya
Author: Emmanuel Balandya
Author: Khadija Msami
Author: Deogratias Soka
Author: Sharon E. Cox
Author: Albert N Komba
Author: Stella Rwezaula
Author: Elineema Meda
Author: David Muturi
Author: Jesse Kitundu
Author: Gregory Fegan
Author: Fenella J. Kirkham ORCID iD
Author: Charles R Newton
Author: Robert W Snow
Author: Brett Lowe

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