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Review article: enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer

Review article: enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer
Review article: enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer

Background: Over 11 000 UK patients each year develop pancreatic exocrine insufficiency - the major causes are not rare: cystic fibrosis (>300 new cases/year), pancreatic cancer (>7000 new cases/year) and chronic pancreatitis (>4000 new cases/year). Affected patients present in diverse ways, and for chronic pancreatitis, diagnosis is frequently made rather late in the course of the disease. Aim: To raise awareness of key clinical issues specific to patients with pancreatic exocrine insufficiency through experience from UK clinicians, and to offer advice regarding appropriate treatment with pancreatic enzymes. Methods: Three case studies describe clinical issues relating to pancreatic enzyme supplementation that may lead to underuse in patients with cystic fibrosis, pancreatic and periampullary cancer or chronic pancreatitis. Results: The efficacy of the treatment of exocrine pancreatic insufficiency is dependent on adequate meal:time enzyme replacement therapy. Improvements in patients' weight and nutritional status are what is aimed for - an important reason for all doctors, nurses and dieticians to give this therapy close attention. Conclusions: Pancreatic exocrine insufficiency may result in malnutrition, but enzyme supplementation can greatly improve quality of life in these patients.

0269-2813
1-25
Imrie, C.W.
826fae61-a279-410e-bbc4-b41f2e27e385
Connett, G.
55d5676c-90d8-46bf-a508-62eded276516
Hall, R.I.
bd34f4ea-defe-4fec-8a3b-485ea277898f
Charnley, R.M.
406132c5-f6d4-43f7-a2c6-57b72bfbef3a
Imrie, C.W.
826fae61-a279-410e-bbc4-b41f2e27e385
Connett, G.
55d5676c-90d8-46bf-a508-62eded276516
Hall, R.I.
bd34f4ea-defe-4fec-8a3b-485ea277898f
Charnley, R.M.
406132c5-f6d4-43f7-a2c6-57b72bfbef3a

Imrie, C.W., Connett, G., Hall, R.I. and Charnley, R.M. (2010) Review article: enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer. Alimentary pharmacology & therapeutics, 32 (SUPPL. 1), 1-25. (doi:10.1111/j.1365-2036.2010.04437.x).

Record type: Review

Abstract

Background: Over 11 000 UK patients each year develop pancreatic exocrine insufficiency - the major causes are not rare: cystic fibrosis (>300 new cases/year), pancreatic cancer (>7000 new cases/year) and chronic pancreatitis (>4000 new cases/year). Affected patients present in diverse ways, and for chronic pancreatitis, diagnosis is frequently made rather late in the course of the disease. Aim: To raise awareness of key clinical issues specific to patients with pancreatic exocrine insufficiency through experience from UK clinicians, and to offer advice regarding appropriate treatment with pancreatic enzymes. Methods: Three case studies describe clinical issues relating to pancreatic enzyme supplementation that may lead to underuse in patients with cystic fibrosis, pancreatic and periampullary cancer or chronic pancreatitis. Results: The efficacy of the treatment of exocrine pancreatic insufficiency is dependent on adequate meal:time enzyme replacement therapy. Improvements in patients' weight and nutritional status are what is aimed for - an important reason for all doctors, nurses and dieticians to give this therapy close attention. Conclusions: Pancreatic exocrine insufficiency may result in malnutrition, but enzyme supplementation can greatly improve quality of life in these patients.

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Published date: November 2010

Identifiers

Local EPrints ID: 420610
URI: http://eprints.soton.ac.uk/id/eprint/420610
ISSN: 0269-2813
PURE UUID: 84a4c423-3f65-43d7-90f8-2fa31e28268f
ORCID for G. Connett: ORCID iD orcid.org/0000-0003-1310-3239

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Date deposited: 10 May 2018 16:31
Last modified: 05 Nov 2019 01:23

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