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The structure of the perivascular compartment in the old canine brain: a case study

The structure of the perivascular compartment in the old canine brain: a case study
The structure of the perivascular compartment in the old canine brain: a case study

Dilatation of periarteriolar spaces in MRI of the ageing human brains occurs in white matter (WM), basal ganglia and midbrain but not in cerebral cortex. Perivenous collagenous occurs in periventricular but not in subcortical WM.Here we test the hypotheses that (a) the capacity for dilatation of periarteriolar spaces correlates with the anatomical distribution of leptomeningeal cells coating intracerebral arteries and (b) the regional development of perivenous collagenous in the WM correlates with the population of intramural cells in the walls of veins.The anatomical distribution of leptomeningeal and intramural cells related to cerebral blood vessels is best documented by electron microscopy, requiring perfusion-fixed tissue not available in human material. We therefore analysed perfusion-fixed brain from a 12-year-old Beagle dog as the canine brain represents the anatomical arrangement in the human brain. Results showed regional variation in the arrangement of leptomeningeal cells around blood vessels. Arterioles are enveloped by one complete layer of leptomeninges often with a second incomplete layer in the WM. Venules showed incomplete layers of leptomeningeal cells. Intramural cell expression was higher in the post-capillary venules of the subcortical WM when compared with periventricular WM, suggesting that periventricular collagenosis around venules may be due to a lower resistance in the venular walls. It appears that the regional variation in the capacity for dilatation of arteriolar perivascular spaces in the white WM may be related to the number of perivascular leptomeningeal cells surrounding vessels in different areas of the brain.

Aging, Animals, Arterioles, Brain, Dogs, White Matter, Journal Article
0143-5221
2737-2744
Criswell, Theodore P.
e13e2b82-4f3b-4ca0-a2ba-aebd4c3eddbf
Sharp, Matthew MacGregor
ec57c53a-a10a-4b8a-94fe-03eca85ab7c3
Dobson, Howard
fae4e9b8-c96c-4d5a-b445-359fd9713d52
Finucane, Ciara
d50dd8c0-ac51-4e0e-94c5-6251187dbfba
Weller, Roy O.
4a501831-e38a-4d39-a125-d7141d6c667b
Verma, Ajay
5a207350-0de9-487a-be28-f9eb2f558140
Carare, Roxana O
0478c197-b0c1-4206-acae-54e88c8f21fa
Criswell, Theodore P.
e13e2b82-4f3b-4ca0-a2ba-aebd4c3eddbf
Sharp, Matthew MacGregor
ec57c53a-a10a-4b8a-94fe-03eca85ab7c3
Dobson, Howard
fae4e9b8-c96c-4d5a-b445-359fd9713d52
Finucane, Ciara
d50dd8c0-ac51-4e0e-94c5-6251187dbfba
Weller, Roy O.
4a501831-e38a-4d39-a125-d7141d6c667b
Verma, Ajay
5a207350-0de9-487a-be28-f9eb2f558140
Carare, Roxana O
0478c197-b0c1-4206-acae-54e88c8f21fa

Criswell, Theodore P., Sharp, Matthew MacGregor, Dobson, Howard, Finucane, Ciara, Weller, Roy O., Verma, Ajay and Carare, Roxana O (2017) The structure of the perivascular compartment in the old canine brain: a case study. Clinical Science, 131 (22), 2737-2744. (doi:10.1042/CS20171278).

Record type: Article

Abstract

Dilatation of periarteriolar spaces in MRI of the ageing human brains occurs in white matter (WM), basal ganglia and midbrain but not in cerebral cortex. Perivenous collagenous occurs in periventricular but not in subcortical WM.Here we test the hypotheses that (a) the capacity for dilatation of periarteriolar spaces correlates with the anatomical distribution of leptomeningeal cells coating intracerebral arteries and (b) the regional development of perivenous collagenous in the WM correlates with the population of intramural cells in the walls of veins.The anatomical distribution of leptomeningeal and intramural cells related to cerebral blood vessels is best documented by electron microscopy, requiring perfusion-fixed tissue not available in human material. We therefore analysed perfusion-fixed brain from a 12-year-old Beagle dog as the canine brain represents the anatomical arrangement in the human brain. Results showed regional variation in the arrangement of leptomeningeal cells around blood vessels. Arterioles are enveloped by one complete layer of leptomeninges often with a second incomplete layer in the WM. Venules showed incomplete layers of leptomeningeal cells. Intramural cell expression was higher in the post-capillary venules of the subcortical WM when compared with periventricular WM, suggesting that periventricular collagenosis around venules may be due to a lower resistance in the venular walls. It appears that the regional variation in the capacity for dilatation of arteriolar perivascular spaces in the white WM may be related to the number of perivascular leptomeningeal cells surrounding vessels in different areas of the brain.

Full text not available from this repository.

More information

Accepted/In Press date: 3 October 2017
e-pub ahead of print date: 13 November 2017
Published date: 15 November 2017
Additional Information: © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
Keywords: Aging, Animals, Arterioles, Brain, Dogs, White Matter, Journal Article

Identifiers

Local EPrints ID: 420658
URI: https://eprints.soton.ac.uk/id/eprint/420658
ISSN: 0143-5221
PURE UUID: 5e603619-ade3-4fc1-b515-ffb246d02bcb
ORCID for Matthew MacGregor Sharp: ORCID iD orcid.org/0000-0002-6623-5078

Catalogue record

Date deposited: 11 May 2018 16:30
Last modified: 03 Dec 2019 01:41

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