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Low-complexity hardware design methodology for reliable and automated removal of ocular and muscular artifact from EEG

Low-complexity hardware design methodology for reliable and automated removal of ocular and muscular artifact from EEG
Low-complexity hardware design methodology for reliable and automated removal of ocular and muscular artifact from EEG

Background and objective: EEG is a non-invasive tool for neuro-developmental disorder diagnosis and treatment. However, EEG signal is mixed with other biological signals including Ocular and Muscular artifacts making it difficult to extract the diagnostic features. Therefore, the contaminated EEG channels are often discarded by the medical practitioners which may result in less accurate diagnosis. Many existing methods require reference electrodes, which will create discomfort to the patient/children and cause hindrance to the diagnosis of the neuro-developmental disorder and Brain Computer Interface in the pervasive environment. Therefore, it would be ideal if these artifacts can be removed real time on the hardware platform in an automated fashion and then the denoised EEG can be used for online diagnosis in a pervasive personalized healthcare environment without the need of any reference electrode. Methods: In this paper we propose a reliable, robust and automated methodology to solve the aforementioned problem. The proposed methodology is based on the Haar function based Wavelet decompositions with simple threshold based wavelet domain denoising and artifacts removal schemes. Subsequently hardware implementation results are also presented. 100 EEG data from Physionet, Klinik für Epileptologie, Universität Bonn, Germany, Caltech EEG databases and 7 EEG data from 3 subjects from University of Southampton, UK have been studied and nine exhaustive case studies comprising of real and simulated data have been formulated and tested. The proposed methodology is prototyped and validated using FPGA platform. Results: Like existing literature, the performance of the proposed methodology is also measured in terms of correlation, regression and R-square statistics and the respective values lie above 80%, 79% and 65% with the gain in hardware complexity of 64.28% and improvement in hardware delay of 53.58% compared to state-of-the art approaches. Hardware design based on the proposed methodology consumes 75 micro-Watt power. Conclusions: The automated methodology proposed in this paper, unlike the state of the art methods, can remove blink and muscular artifacts real time without the need of any extra electrode. Its reliability and robustness is also established after exhaustive simulation study and analysis on both simulated and real data. We believe the proposed methodology would be useful in next generation personalized pervasive healthcare for Brain Computer Interface and neuro-developmental disorder diagnosis and treatment.

Brain Computer Interface (BCI), Denoising, Discrete wavelet transform, Electroencephalography, Independent component analysis, Muscular and ocular artifact removal
0169-2607
123-133
Acharyya, Amit
1f8a0620-1c00-4306-a64c-5185ede71f38
Jadhav, Pranit N.
2038d996-5db8-4057-a2c4-5e764fccfb59
Bono, Valentina
41b6a628-7777-4fa9-b658-2c27165fd29b
Maharatna, Koushik
93bef0a2-e011-4622-8c56-5447da4cd5dd
Naik, Ganesh R.
cc7ae1e0-d036-41d0-a651-dddaca44fcdd
Acharyya, Amit
1f8a0620-1c00-4306-a64c-5185ede71f38
Jadhav, Pranit N.
2038d996-5db8-4057-a2c4-5e764fccfb59
Bono, Valentina
41b6a628-7777-4fa9-b658-2c27165fd29b
Maharatna, Koushik
93bef0a2-e011-4622-8c56-5447da4cd5dd
Naik, Ganesh R.
cc7ae1e0-d036-41d0-a651-dddaca44fcdd

Acharyya, Amit, Jadhav, Pranit N., Bono, Valentina, Maharatna, Koushik and Naik, Ganesh R. (2018) Low-complexity hardware design methodology for reliable and automated removal of ocular and muscular artifact from EEG. Computer Methods and Programs in Biomedicine, 158, 123-133. (doi:10.1016/j.cmpb.2018.02.009).

Record type: Article

Abstract

Background and objective: EEG is a non-invasive tool for neuro-developmental disorder diagnosis and treatment. However, EEG signal is mixed with other biological signals including Ocular and Muscular artifacts making it difficult to extract the diagnostic features. Therefore, the contaminated EEG channels are often discarded by the medical practitioners which may result in less accurate diagnosis. Many existing methods require reference electrodes, which will create discomfort to the patient/children and cause hindrance to the diagnosis of the neuro-developmental disorder and Brain Computer Interface in the pervasive environment. Therefore, it would be ideal if these artifacts can be removed real time on the hardware platform in an automated fashion and then the denoised EEG can be used for online diagnosis in a pervasive personalized healthcare environment without the need of any reference electrode. Methods: In this paper we propose a reliable, robust and automated methodology to solve the aforementioned problem. The proposed methodology is based on the Haar function based Wavelet decompositions with simple threshold based wavelet domain denoising and artifacts removal schemes. Subsequently hardware implementation results are also presented. 100 EEG data from Physionet, Klinik für Epileptologie, Universität Bonn, Germany, Caltech EEG databases and 7 EEG data from 3 subjects from University of Southampton, UK have been studied and nine exhaustive case studies comprising of real and simulated data have been formulated and tested. The proposed methodology is prototyped and validated using FPGA platform. Results: Like existing literature, the performance of the proposed methodology is also measured in terms of correlation, regression and R-square statistics and the respective values lie above 80%, 79% and 65% with the gain in hardware complexity of 64.28% and improvement in hardware delay of 53.58% compared to state-of-the art approaches. Hardware design based on the proposed methodology consumes 75 micro-Watt power. Conclusions: The automated methodology proposed in this paper, unlike the state of the art methods, can remove blink and muscular artifacts real time without the need of any extra electrode. Its reliability and robustness is also established after exhaustive simulation study and analysis on both simulated and real data. We believe the proposed methodology would be useful in next generation personalized pervasive healthcare for Brain Computer Interface and neuro-developmental disorder diagnosis and treatment.

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More information

Accepted/In Press date: 2 February 2018
e-pub ahead of print date: 7 February 2018
Published date: 1 May 2018
Keywords: Brain Computer Interface (BCI), Denoising, Discrete wavelet transform, Electroencephalography, Independent component analysis, Muscular and ocular artifact removal

Identifiers

Local EPrints ID: 420709
URI: https://eprints.soton.ac.uk/id/eprint/420709
ISSN: 0169-2607
PURE UUID: c07343f6-b2e4-4448-adf5-148ad5d128c9

Catalogue record

Date deposited: 11 May 2018 16:30
Last modified: 13 Mar 2019 18:50

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