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Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI

Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI
Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI
Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1–4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study (n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2.5 μm (PM2.5) in the first trimester had an adjusted incidence rate ratio (IRR) (95% confidence interval (CI)) of 1.85 (1.23–2.78), 1.76 (1.08–2.85) and 1.90 (1.10–3.27) in quartile (Q) 2–4, with reference to Q1. This association is seen in the second trimester for bronchiolitis/bronchitis. The risk of ear infection in the first year of life was associated with exposure to PM2.5 in the first trimester with adjusted Odds Ratio (adjOR) (95% CI) = 7.64 (1.18–49.37), 11.37 (1.47–87.97) and 8.26 (1.13–60.29) for Q2–4, and similarly in the second year with adjOR (95% CI) = 3.28 (1.00–10.73) and 4.15 (1.05–16.36) for Q2–3. Prenatal exposure to air pollution has an enhanced impact on childhood respiratory health, and differs according to maternal pre-pregnancy BMI.
1660-4601
Soh, Shu-E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Goh, Anne
75c7945a-718e-4b10-ab57-a643ccd71536
Teoh, Oon Hoe
1f6973b2-81c6-4749-bef0-d4f09a7ce738
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Shek, Lynette Pei-Chi
ff5b44bf-5ab5-4249-8cf1-21751a4f6ae8
Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136
Soh, Shu-E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Goh, Anne
75c7945a-718e-4b10-ab57-a643ccd71536
Teoh, Oon Hoe
1f6973b2-81c6-4749-bef0-d4f09a7ce738
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Shek, Lynette Pei-Chi
ff5b44bf-5ab5-4249-8cf1-21751a4f6ae8
Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136

Soh, Shu-E., Goh, Anne, Teoh, Oon Hoe, Godfrey, Keith M., Gluckman, Peter D., Shek, Lynette Pei-Chi and Chong, Yap-Seng (2018) Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI. International Journal of Environmental Research and Public Health, 15 (5). (doi:10.3390/ijerph15050996).

Record type: Article

Abstract

Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1–4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study (n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2.5 μm (PM2.5) in the first trimester had an adjusted incidence rate ratio (IRR) (95% confidence interval (CI)) of 1.85 (1.23–2.78), 1.76 (1.08–2.85) and 1.90 (1.10–3.27) in quartile (Q) 2–4, with reference to Q1. This association is seen in the second trimester for bronchiolitis/bronchitis. The risk of ear infection in the first year of life was associated with exposure to PM2.5 in the first trimester with adjusted Odds Ratio (adjOR) (95% CI) = 7.64 (1.18–49.37), 11.37 (1.47–87.97) and 8.26 (1.13–60.29) for Q2–4, and similarly in the second year with adjOR (95% CI) = 3.28 (1.00–10.73) and 4.15 (1.05–16.36) for Q2–3. Prenatal exposure to air pollution has an enhanced impact on childhood respiratory health, and differs according to maternal pre-pregnancy BMI.

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Accepted/In Press date: 12 May 2018
e-pub ahead of print date: 15 May 2018

Identifiers

Local EPrints ID: 420917
URI: https://eprints.soton.ac.uk/id/eprint/420917
ISSN: 1660-4601
PURE UUID: 9cfd4fae-184f-414b-87cf-6eeaf74194a8
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 18 May 2018 16:30
Last modified: 10 Dec 2019 01:57

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Contributors

Author: Shu-E. Soh
Author: Anne Goh
Author: Oon Hoe Teoh
Author: Peter D. Gluckman
Author: Lynette Pei-Chi Shek
Author: Yap-Seng Chong

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